Evidence map›Paper›PMID 37974928›Full record

Article3 Biotech2023

Unveiling the anti-glioma potential of a marine derivative, Fucoidan: its synergistic cytotoxicity with Temozolomide-an in vitro and in silico experimental study.

Indrani Biswas, Daisy S Precilla, Shreyas S Kuduvalli, Muralidharan Arumugam Ramachandran, S Akshaya, Venkat Raman, Dhamodharan Prabhu, T S Anitha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in 3 Biotech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Indrani Biswas *Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, 607402 India.
Daisy S Precilla *Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, 607402 India.
Shreyas S KuduvalliMahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, 607402 India.
Muralidharan Arumugam RamachandranDepartment of Visual Neurosciences, Singapore Eye Research Institute, Singapore, 169856 Singapore.
S AkshayaJeppiaar College of Engineering, Chennai, Tamil Nadu 600119 India.
Venkat RamanThiruvalluvar University, Vellore, Tamil Nadu 632115 India.
Dhamodharan PrabhuCentre for Drug Discovery, Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, 641021 India.
T S AnithaMahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, 607402 India.ORCID 0000-0003-2326-8547
Sri Balaji Vidyapeeth University · INKarpagam Academy of Higher Education · INPondicherry University · INSathyabama Institute of Science and Technology · INSingapore Eye Research Institute · SGThiruvalluvar University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma coined as a "butterfly" tumor associated with a dismal prognosis. Marine algal compounds with the richest sources of bioactive components act as significant anti-tumor therapeutics. However, there is a paucity of studies conducted on Fucoidan to enhance the anti-glioma efficacy of Temozolomide. Therefore, the present study aimed to evaluate the synergistic anti-proliferative, anti-inflammatory and pro-apoptotic effects of Fucoidan with Temozolomide in in vitro and in silico experimental setup Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-023-03814-6.

Indexed as

Drug repurposingGliomaInflammatory and apoptotic markersMolecular docking and simulation

Identifiers

PMID37974928
PMCPMC10645720
OpenAlexW4388670979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.