Evidence map›Paper›PMID 37974363›Full record

ArticleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2023

OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.

David C S Wong, Joshua P Harvey, Neringa Jurkute, Sara M Thomasy, Mariya Moosajee, Patrick Yu-Wai-Man, Michael J Gilhooley

Abstract read
In one paragraph

Article in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Rhesus macaques with anProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy.International journal of molecular sciences · 2025
    Article
  7. Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David C S WongDepartment of Clinical Neurosciences (DCSW, PY-W-M), John van Geest Center for Brain Repair, University of Cambridge, Cambridge, United Kingdom; Cambridge Eye Unit (DCSW, PY-W-M), Addenbrooke's Hospital, Cambridge, United Kingdom; UCL Institute of Ophthalmology (JPH, NJ, MM, PY-W-M, MJG), London, United Kingdom; Moorfields Eye Hospital NHS Foundation Trust (JPH, NJ, MM, PY-W-M, MJG), London, United Kingdom; Department of Ophthalmology and Vision Science (SMT), School of Medicine, U.C. Davis, Sacramento, California; Department of Surgical and Radiological Sciences (SMT), School of Veterinary Medicine, U.C. Davis, California; Great Ormond Street Hospital (MM), London, United Kingdom; and The Francis Crick Institute (MM), London, United Kingdom.ORCID 0000-0002-1712-9527
Joshua P Harvey
Neringa Jurkute
Sara M Thomasy
Mariya Moosajee
Patrick Yu-Wai-Man
Michael J GilhooleyORCID 0000-0003-4109-5336

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI W MARTIN USREY · 1999 to 2026
$18.9M
Novel Model Systems for the Study of Cone Disorders and Other Heritable Retinal DiseasesU24EY029904 · NEI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI, ROGERS, JEFFREY A. · 2018 to 2023
$7.7M
Diversity Supplement: Advancing novel therapies for optic neuropathy with a nonhuman primate modelR01EY033733 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Sara Michelle Thomasy · 2023 to 2026
$2.9M
Medical Research Council G0701386Medical Research Council G1002570NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY033733NEI NIH HHS U24 EY029904NIH HHS P51 OD011107Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Optic AtrophyOptic Atrophy, Autosomal DominantGTP PhosphohydrolasesHumansMutationGTP PhosphohydrolasesOPA1 protein, human

Identifiers

PMID37974363
PMCPMC10645107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.