Evidence map›Paper›PMID 37974301›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke.

Shiyi Zhou, Chang Liu, Jixian Wang, Jing Ye, Qianyuan Lian, Lin Gan, Shiyu Deng, Tongtong Xu, Yiyan Guo, Wanlu Li and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Intraparenchymal B cell therapy protects neurological function and modulates local neuroinflammation in experimental hemorrhagic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  5. Review
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  7. Review
  8. Article
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  11. Article
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  14. Loss-of-function mutations of microRNA-142-3p promoteWorld journal of gastroenterology · 2025
    Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Shiyi ZhouShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Chang LiuShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jixian WangDepartment of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing YeShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Qianyuan LianShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Lin GanShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Shiyu DengShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Tongtong XuShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yiyan GuoShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wanlu LiShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zhijun ZhangShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Guo-Yuan YangShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yaohui TangShanghai Sixth People's Hospital and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-9603-2650
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The crosstalk between reactive astrocytes and infiltrated immune cells plays a critical role in maintaining blood-brain barrier (BBB) integrity. However, how astrocytes interact with immune cells and the effect of their interaction on BBB integrity after hemorrhagic stroke are still unclear. By performing RNA sequencing in astrocytes that were activated by interleukin-1α (IL-1α), tumor necrosis factor α (TNFα), and complement component 1q (C1q) treatment, we found CCL5 was among the top upregulated genes. Immunostaining and western blot results demonstrated that CCL5 was increased in mice brain after hemorrhagic stroke. Flow cytometry showed that knockout of astrocytic CCL5 reduced the infiltration of CD8

Indexed as

Blood-Brain BarrierChemokine CCL5Hemorrhagic StrokeAnimalsAstrocytesCD8-Positive T-LymphocytesCell CommunicationEndothelial CellsMicePerforinCcl5 protein, mouseChemokine CCL5PerforinAstrocytesblood-brain barrierCCL5intracerebral hemorrhageT cells

Identifiers

PMID37974301
PMCPMC10870968
OpenAlexW4388773195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.