Evidence map›Paper›PMID 37974254›Full record

SynthesisEuropean journal of medical research2023

Relationship between neutrophil to lymphocyte ratio and diabetic peripheral neuropathy: a systematic review and meta-analysis.

Armin Rezaei Shahrabi, Gabrielle Arsenault, Seyed Ali Nabipoorashrafi, Brandon Lucke-Wold, Shirin Yaghoobpoor, Fatemeh Zari Meidani, Rahem Rahmati, Arshin Ghaedi, Shokoufeh Khanzadeh

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Armin Rezaei ShahrabiDepartment of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran.
Gabrielle ArsenaultDepartment of Neurosurgery, University of Florida, Gainesville, USA.
Seyed Ali NabipoorashrafiEndocrinology and Metabolism Research Center (EMRC), School of Medicine, Vali-Asr Hospital, Tehran, Iran.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, USA.
Shirin YaghoobpoorStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh Zari MeidaniStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Rahem RahmatiStudents Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Arshin GhaediStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shokoufeh KhanzadehTabriz University of Medical Sciences, Tabriz, Iran. khshokufe7@gmail.com.
Shahrekord University of Medical Sciences · IRUniversity of Florida · USIslamic Azad University, Damghan Branch · IRShahid Beheshti University of Medical Sciences · IRShiraz University of Medical Sciences · IRTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study aims to review the existing scientific literature on the role of neutrophil to lymphocyte ratio (NLR) in diabetic peripheral neuropathy (DPN) to perform a meta-analysis on the available data.

methodsThe electronic repositories Web of Science, PubMed, and Scopus were systematically explored starting from their establishment up until June 9, 2022.

resultsFifteen articles were included in the meta-analysis after multiple screening according to the PRISMA guidelines. The combined findings indicated that individuals with DPN had higher levels of NLR in comparison to those without DPN (SMD = 0.61; CI 95% = 0.40-0.81, p < 0.001). In the subgroup assessment based on ethnicity, it was observed that diabetic patients with DPN exhibited increased NLR levels in contrast to those without DPN in studies conducted in India (SMD = 1.30; CI 95% = 0.37-2.24, p = 0.006) and East Asia (SMD = 0.53; CI 95% = 0.34-0.73, p < 0.001) but not in studies conducted in Turkey (SMD = 0.30; CI 95% = - 0.06-0.67, p = 0.104) and Egypt (SMD = 0.34; CI 95% = -0.14-0.82, p = 0.165). The pooled sensitivity of NLR was 0.67 (95% CI = 0.49-0.81), and the pooled specificity was 0.70 (95% CI, 0.56-0.81). The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR) of NLR were 2.30 (95% CI = 1.71-3.09), 0.45 (95%CI = 0.30-0.67), and 5.06 (95% CI = 3.16-8.12), respectively.

conclusionNLR serves as a distinct marker of inflammation, and its rise in cases of DPN suggests an immune system imbalance playing a role in the development of the disease.

Indexed as

Diabetes MellitusDiabetic NeuropathiesHumansIndiaLymphocytesNeutrophilsTurkey

Identifiers

PMID37974254
PMCPMC10652461
OpenAlexW4388724935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.