ArticleEnvironmental microbiome2023
Designing a synthetic microbial community through genome metabolic modeling to enhance plant-microbe interaction.
Article in Environmental microbiome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Challenges and Future Directives of Synthetic Biology in Engineering Plant-Microbe Partnerships for Sustainable Agriculture.Biotechnology and bioengineering · 2026Review
- It takes a village: how plant-associated bacterial communities socialise to shape plant growth and health.Essays in biochemistry · 2026Review
- From diet to function: using synthetic microbial communities to map gut microbial interactions.NPJ biofilms and microbiomes · 2026Review
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Anthracnose drives assembly of phyllosphere epiphytic bacterial communities to increase disease resistance.NPJ biofilms and microbiomes · 2026Article
- A 'Genome-First' Framework for Next-Generation Bioinputs: From Functional Mining to Rational Synthetic Microbial Communities.Environmental microbiology · 2026Review
- Metabolome-driven rhizosphere microbiome assembly determining the health of medicinal herb (Angelica sinensis) against root rot.Microbiome · 2026Article
- Water kefir as a paradigm for multi-omics and genome-scale metabolic modelling in fermented food.NPJ biofilms and microbiomes · 2026Review
- Identification of bacterial candidates that promote the growth of the seagrassbioRxiv : the preprint server for biology · 2026Article
- Ecology-guided Bacillus SynCom from a rice-duckweed core reveals division of labor for concurrent growth promotion and sheath blight suppression.Microbiome · 2026Article
- Review
- Harnessing Plant-Microorganism Interactions to Mitigate Biotic and Abiotic Stresses for Sustainable Crops.Plants (Basel, Switzerland) · 2026Review
- Beyond the Single Isolate: Leveraging Plant-Associated Microbial Communities for Crop Resilience.Microorganisms · 2026Review
- Ecological drift simulations reveal key factors influencing minimal microbiome engineering and community assembly.ISME communications · 2026Article
- Diagnosing soil bioremediation failure: evidence-weighted pathways from mechanism to field closure.Frontiers in bioengineering and biotechnology · 2026Review
- Plant microbiome engineering: from inoculation to genome editing.Frontiers in microbiology · 2026Review
- Synthetic microbial communities: a novel emerging models for dissecting gut microbiota-host interactions in neurodegenerative diseases.Frontiers in immunology · 2026Review
- Arbuscular Mycorrhizal Fungi as Core Engineers in Synthetic Microbial Communities: Boosting Plant Growth and Soil Health for Sustainable Agriculture.Journal of fungi (Basel, Switzerland) · 2025Review
- Diverse Members of the PhylumInternational journal of molecular sciences · 2025Article
- Host-independent synergism between Lactobacillus crispatus and other vaginal lactobacilli.Cell reports · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundManipulating the rhizosphere microbial community through beneficial microorganism inoculation has gained interest in improving crop productivity and stress resistance. Synthetic microbial communities, known as SynComs, mimic natural microbial compositions while reducing the number of components. However, achieving this goal requires a comprehensive understanding of natural microbial communities and carefully selecting compatible microorganisms with colonization traits, which still pose challenges. In this study, we employed multi-genome metabolic modeling of 270 previously described metagenome-assembled genomes from Campos rupestres to design a synthetic microbial community to improve the yield of important crop plants.
resultsWe used a targeted approach to select a minimal community (MinCom) encompassing essential compounds for microbial metabolism and compounds relevant to plant interactions. This resulted in a reduction of the initial community size by approximately 4.5-fold. Notably, the MinCom retained crucial genes associated with essential plant growth-promoting traits, such as iron acquisition, exopolysaccharide production, potassium solubilization, nitrogen fixation, GABA production, and IAA-related tryptophan metabolism. Furthermore, our in-silico selection for the SymComs, based on a comprehensive understanding of microbe-microbe-plant interactions, yielded a set of six hub species that displayed notable taxonomic novelty, including members of the Eremiobacterota and Verrucomicrobiota phyla.
conclusionOverall, the study contributes to the growing body of research on synthetic microbial communities and their potential to enhance agricultural practices. The insights gained from our in-silico approach and the selection of hub species pave the way for further investigations into the development of tailored microbial communities that can optimize crop productivity and improve stress resilience in agricultural systems.
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