Evidence map›Paper›PMID 37974136›Full record

Trial reportBMC oral health2023

A tangible prospect for the treatment of gingivitis using a potentially probiotic strain Lactobacillus plantarum MK06 isolated from traditional dairy products: a triple blind randomized clinical trial.

Sima Modiri, Mohadeseh Heidari, Rojin Shahmohammadi, Leila Jabbareh, Avideh Maboudi, Mahmood Moosazadeh, Hojatollah Vali, Kambiz Akbari Noghabi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sima Modiri *National Institute of Genetic Engineering and Biotechnology (NIGEB), P. O. Box 14155-6343, Tehran, Iran.
Mohadeseh Heidari *Department of Periodontology, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Rojin ShahmohammadiDepartment of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Leila JabbarehDepartment of Periodontology, Faculty of Dentistry, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Avideh MaboudiDepartment of Periodontology, Faculty of Dentistry, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Mahmood MoosazadehGastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Hojatollah ValiDepartment of Anatomy & Cell Biology, McGill University, 3640 Street, Montreal, QC, H3A 0C7, Canada.
Kambiz Akbari NoghabiNational Institute of Genetic Engineering and Biotechnology (NIGEB), P. O. Box 14155-6343, Tehran, Iran. Akbari@nigeb.ac.ir.
Mazandaran University of Medical Sciences · IRNational Institute of Genetic Engineering and Biotechnology · IRMcGill University · CATehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrequent bacterial plaque buildup at the gingival margin and crevice can provoke an inflammatory reaction in gingival tissues which manifests as gingivitis. Probiotics could serve as a beneficial complementary therapy for treating gingival inflammation. The main aim of this research was to investigate the effect of the Lactobacillus plantarum MK06 probiotic strain on the treatment of gingivitis.

methodsPatients with gingivitis, who were referred to a private clinic and were systematically healthy, were included in this randomized, triple-blind, placebo-controlled trial. They were instructed to use either placebo or Lactobacillus plantarum suspensions for one minute two times a day after tooth-brushing for four weeks. Then, the clinical parameters of gingivitis, including plaque index (PI), gingival index (GI), bleeding on probing (BOP), and oral hygiene index (OHI-s), were measured in the first, second, and fourth weeks. A total of forty-two patients were randomly assigned to the experimental (n = 21) and control (n = 21) groups. The mean age of the experimental and control groups was 29.10 and 28.48, respectively.

resultsThe mean scores of BOP, GI, PI, and OHI-s reduced over time in both the control and test groups. However, according to the Mann-Whitney test, the difference between the two groups was not significant at the same time intervals (P ≥ 0.05) and only GI showed a significant difference in the fourth week (GI-3, P = 0.006). Nevertheless, the experimental group experienced a higher overall reduction rate than the control group. The BOP, GI, PI, and OHI-s scores decreased by 0.081, 0.204, 0.186, and 0.172 times in the second week, respectively, resulting from the interaction of time and the intervention, which considerably diminished these indices.

conclusionThis study shows the potential of the probiotic Lactobacillus plantarum MK06 suspension as a promoting therapeutic adjuvant in the treatment of gingivitis.

Indexed as

GingivitisLactiplantibacillus plantarumProbioticsDairy ProductsDental Plaque IndexGingivaHumansDairy productsDental plaque indexGingival indexGingivitisLactobacillus plantarum MK06MouthwashesOral healthProbiotics

Identifiers

PMID37974136
PMCPMC10655419
OpenAlexW4388719631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.