ReviewCommunications medicine2023
Unearthing the mechanisms of responsive neurostimulation for epilepsy.
Review in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
- Early assessment of responsive neurostimulation for drug-resistant epilepsy in China: A multicenter, self-controlled study.Chinese medical journal · 2025Trial
- Bilateral detection, prediction, and lateralization of seizures using white matter.Epilepsia open · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Beneath the Spike: Laminar Microcircuits of Human Interictal Epileptiform Discharges.Epilepsy currents · 2026Article
- Clusters in Thalamic iEEG Spectral Features Reveal Sleep/Wake Differences Over Time.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Article
- Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement.medRxiv : the preprint server for health sciences · 2026Article
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Stabilizing fractional dynamical networks suppresses epileptic seizures.Scientific reports · 2026Article
- Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures.bioRxiv : the preprint server for biology · 2026Article
- Magnetoelectric Nanoparticle-Based Wireless Brain-Computer Interface: Underlying Physics and Projected Technology Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Responsive neurostimulation in children, adolescents, and young Adults-Longitudinal effectiveness and safety.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Leveraging epileptic network understanding to improve targeted treatment.PLoS biology · 2026Article
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- Centromedian nucleus targeting in the pediatric population treated with thalamic responsive neurostimulation for drug-resistant epilepsy.Epilepsia open · 2026Article
- Laser interstitial thermal therapy with a previously implanted responsive neurostimulation device: a multicenter experience. Illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- Toward Unified Biomarkers for Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Modern Aspects of Invasive Epilepsy Monitoring: Utility for Seizure Localization and Therapeutic Decision-Making.Pediatric neurosurgery · 2026Review
- The bed nucleus of the stria terminalis as a neuromodulatory target for refractory epilepsy.Frontiers in network physiology · 2026Review
- 50 Hz Cortical stimulation increases interictal epileptiform discharges at the seizure onset zone.Brain communications · 2026Article
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Responsive neurostimulation (RNS) is an effective therapy for people with drug-resistant focal epilepsy. In clinical trials, RNS therapy results in a meaningful reduction in median seizure frequency, but the response is highly variable across individuals, with many receiving minimal or no benefit. Understanding why this variability occurs will help improve use of RNS therapy. Here we advocate for a reexamination of the assumptions made about how RNS reduces seizures. This is now possible due to large patient cohorts having used this device, some long-term. Two foundational assumptions have been that the device's intracranial leads should target the seizure focus/foci directly, and that stimulation should be triggered only in response to detected epileptiform activity. Recent studies have called into question both hypotheses. Here, we discuss these exciting new studies and suggest future approaches to patient selection, lead placement, and device programming that could improve clinical outcomes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.