ArticleScientific reports2023
Association of AI-determined Kellgren-Lawrence grade with medial meniscus extrusion and cartilage thickness by AI-based 3D MRI analysis in early knee osteoarthritis.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Evaluating potential for AI automation of quantitative and semi-quantitative MRI scoring in arthritis, especially at the knee: a systematic literature review.Skeletal radiology · 2025Pooled it
- Fully automated 3D MRI assessment of isolated chondral fracture of the knee in an adolescent athlete: A case report.Radiology case reports · 2026Article
- Magnetic resonance imaging-based meniscal coverage and cartilage thickness are associated with mechanical axis alignment in knee osteoarthritis.Journal of experimental orthopaedics · 2026Article
- MRI-Based Deep Learning Image Classification for Screening Temporomandibular Joint Degenerative Joint Disease.Journal of clinical medicine · 2026Article
- Multimodality imaging considerations for genicular artery embolization in knee osteoarthritis.World journal of radiology · 2026Review
- Meniscotibial ligament pockets on MRI are associated with radiographic severity of medial knee osteoarthritis.Scientific reports · 2026Article
- Association between the cartilage area ratio derived from 3D MRI and patient-reported symptoms in medial knee osteoarthritis.Journal of orthopaedic surgery and research · 2026Article
- Predictors of graft signal-to-noise ratio after medial meniscus reconstruction using tendon autograft.Medicine · 2026Article
- Artificial intelligence and big data for precision regenerative medicine in knee osteoarthritis: endotyping, responder prediction, and clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- A systematic review and meta-analysis examining alterations in medial meniscus extrusion and clinical outcomes following high tibial osteotomy.Journal of orthopaedics · 2025Review
- Bone marrow lesion and medial meniscus extrusion width changes following arthroscopic partial meniscectomy for medial meniscal flap tears.Journal of orthopaedic surgery and research · 2025Article
- Same-model and cross-model variability in knee cartilage thickness measurements using 3D MRI systems.PloS one · 2025Article
- 3D-MRI analysis of cartilage thickness changes after PRP injection in medial knee osteoarthritis: A preliminary report.PloS one · 2025Article
- Distribution of interscan measurement error in AI-based 3D MRI analysis of knee cartilage thickness in osteoarthritis.PloS one · 2025Article
- Article
- Predictive factors for coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction.World journal of orthopedics · 2024Article
- Femoral cartilage defects initiate from medial meniscus extrusion or tibial cartilage lesions and expand in knee osteoarthritis as revealed by 3D MRI analysis.Scientific reports · 2024Article
- Minimally Invasive Therapies for Knee Osteoarthritis.Journal of personalized medicine · 2024Review
- Joint line convergence angle is the most associated alignment factor with the severity of medial knee osteoarthritis.Journal of experimental orthopaedics · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The associations among Kellgren-Lawrence (KL) grade, medial meniscus extrusion (MME), and cartilage thickness in knee osteoarthritis (OA) remain insufficiently understood. Our aim was to determine these associations in early to moderate medial tibiofemoral knee OA. We included 469 subjects with no lateral OA from the Kanagawa Knee Study. KL grade was assessed using artificial intelligence (AI) software. The MME was measured by MRI, and the cartilage thickness was evaluated in 18 subregions of the medial femorotibial joint by another AI system. The median MME width was 1.4 mm in KL0, 1.5 mm in KL1, 2.4 mm in KL2, and 6.0 mm in KL3. Cartilage thinning in the medial femur occurred in the anterior central subregion in KL1, expanded inwardly in KL2, and further expanded in KL3. Cartilage thinning in the medial tibia occurred in the anterior and middle external subregions in KL1, expanded into the anterior and middle central subregions in KL2, and further expanded in KL3. The absolute correlation coefficient between MME width and cartilage thickness increased as the KL grade increased in some subregions. This study provides novel insights into the early stages of knee OA and potentially has implications for the development of early intervention strategies.
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