ArticleNature communications2023
Topographic axonal projection at single-cell precision supports local retinotopy in the mouse superior colliculus.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hemispherectomy-Based Optical Window for In Vivo Visualization of Trigeminal Ganglion Neurons in Mice.Bio-protocol · 2026Article
- Absence of local retinotopy in the mouse optic tract.Frontiers in neural circuits · 2026Article
- Parallel Morphological and Functional Development in the Xenopus Retinotectal System.Developmental neurobiology · 2026Article
- Atypical cortical feedback underlies failure to process contextual information in the superior colliculus of Scn2aNature communications · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Intermingled representation of oral cavity in mouse trigeminal ganglion.Scientific reports · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Retinal origin of orientation but not direction selective maps in the superior colliculus.Current biology : CB · 2024Article
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4 authors.
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Abstract
Retinotopy, like all long-range projections, can arise from the axons themselves or their targets. The underlying connectivity pattern, however, remains elusive at the fine scale in the mammalian brain. To address this question, we functionally mapped the spatial organization of the input axons and target neurons in the female mouse retinocollicular pathway at single-cell resolution using in vivo two-photon calcium imaging. We found a near-perfect retinotopic tiling of retinal ganglion cell axon terminals, with an average error below 30 μm or 2° of visual angle. The precision of retinotopy was relatively lower for local neurons in the superior colliculus. Subsequent data-driven modeling ascribed it to a low input convergence, on average 5.5 retinal ganglion cell inputs per postsynaptic cell in the superior colliculus. These results indicate that retinotopy arises largely from topographically precise input from presynaptic cells, rather than elaborating local circuitry to reconstruct the topography by postsynaptic cells.
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