Evidence map›Paper›PMID 37973720›Full record

ArticleNeuroscience bulletin2024

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats.

Jing-Jing Yang, Ying-Xin Liu, Yan-Fang Wang, Bi-Ying Ge, Ying Wang, Qing-Shan Wang, Sheng Li, Jian-Jie Zhang, Ling-Ling Jin, Jau-Shyong Hong and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Jing-Jing Yang *College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.ORCID https://orcid.org/0000-0003-3354-4859
Ying-Xin Liu *College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yan-Fang Wang *College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Bi-Ying GeNational and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian, 116044, China.
Ying WangDepartment of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Qing-Shan WangNational and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian, 116044, China.
Sheng LiCollege of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Jian-Jie ZhangCollege of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Ling-Ling JinNational and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases, Dalian, 116044, China.
Jau-Shyong HongNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, 27709, USA.
Sheng-Ming YinCollege of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China. dlshengming@163.com.
Jie ZhaoCollege of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China. zhaoj@dmu.edu.cn.
Dalian Medical University · CNNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy (TLE). We postulated that kainic acid (KA)-Induced status epilepticus triggers microglia-dependent inflammation, leading to neuronal damage, a lowered seizure threshold, and the emergence of spontaneous recurrent seizures (SRS). Extensive evidence from our laboratory suggests that dextromethorphan (DM), even in ultra-low doses, has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative disease. Our results showed that administration of DM (10 ng/kg per day; subcutaneously via osmotic minipump for 4 weeks) significantly mitigated the residual effects of KA, including the frequency of SRS and seizure susceptibility. In addition, DM-treated rats showed improved cognitive function and reduced hippocampal neuronal loss. We found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91

Indexed as

DextromethorphanEpilepsy, Temporal LobeHippocampusKainic AcidMicrogliaNADPH OxidasesNeuroprotective AgentsRats, Sprague-DawleyAnimalsAnticonvulsantsChronic DiseaseDisease Models, AnimalMaleRatsAnticonvulsantsDextromethorphanKainic AcidNADPH OxidasesNeuroprotective AgentsDextromethorphanNADPH oxidaseTemporal lobe epilepsyUltra-low dose

Identifiers

PMID37973720
PMCPMC11127903
OpenAlexW4388726263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.