Evidence map›Paper›PMID 37973616›Full record

ArticleACS applied materials & interfaces2023

Synthesis and Characterization of Stimuli-Responsive Polymer Brushes in Nanofluidic Channels.

Hadi Rahmaninejad, Andrew J Parnell, Wei-Liang Chen, Nilay Duzen, Thomas Sexton, Gary Dunderdale, John F Ankner, Wim Bras, Christopher K Ober, Anthony J Ryan and 1 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hadi RahmaninejadDepartment of Physics, Virginia Tech, Blacksburg, Virginia 24061, United States.
Andrew J ParnellDepartment of Physics, The University of Sheffield, Sheffield S3 7RH, U.K.ORCID 0000-0001-8606-8644
Wei-Liang ChenDepartment of Material Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-2581-1996
Nilay DuzenDepartment of Material Science and Engineering, Cornell University, Ithaca, New York 14850, United States.
Thomas SextonDepartment of Physics, The University of Sheffield, Sheffield S3 7RH, U.K.
Gary DunderdaleDepartment of Chemical and Biological Engineering, The University of Sheffield, Sheffield S1 3JD, U.K.
John F AnknerSecond Target Station, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States.ORCID 0000-0002-6737-5718
Wim BrasChemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States.ORCID 0000-0001-5070-4039
Christopher K OberDepartment of Material Science and Engineering, Cornell University, Ithaca, New York 14850, United States.ORCID 0000-0002-3805-3314
Anthony J RyanDepartment of Chemistry, The University of Sheffield, Sheffield S3 7HF, U.K.
Rana AshkarCenter for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-4075-2330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanochannels with controllable gating behavior are attractive features in a wide range of nanofluidic applications including viral detection, particle sorting, and flow regulation. Here, we use selective sidewall functionalization of nanochannels with a polyelectrolyte brush to investigate the channel gating response to variations in solution pH and ionic strength. The conformational and structural changes of the interfacial brush layer within the channels are interrogated by specular and off-specular neutron reflectometry. Simultaneous fits of the specular and off-specular signals, using a dynamical theory model and a fitting optimization protocol, enable detailed characterization of the brush conformations and corresponding channel geometry under different solution conditions. Our results indicate a collapsed brush state under basic pH, equivalent to an open gate, and an expanded brush state representing a partially closed gate upon decreasing the pH and salt concentration. These findings open new possibilities in noninvasive in situ characterization of tunable nanofluidics and lab-on-chip devices with advanced designs and improved functionality.

Indexed as

brush conformationsdynamical theory analysisneutron reflectometryoff-specular scatteringpH-responsepolyelectrolyte polymers

Identifiers

PMID37973616
PMCPMC10695172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.