Observational studyAJNR. American journal of neuroradiology2023
Fetal Brain Growth in the Early Second Trimester.
Observational study in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 5 citations in OpenAlex.
- Minor Physical Anomalies and Congenital Malformations Among Children with Psychotic Symptoms: An Exploratory Descriptive Study with Illustrative Clinical Cases.Brain sciences · 2026Article
- Normal growth, sexual dimorphism, and lateral asymmetry of the fetal posterior fossa during the late second and third trimesters.Pediatric radiology · 2026Article
- Prenatal Exposure to Air Pollution and Risk for Attention-Deficit/hyperactivity Disorder in Children.Research on child and adolescent psychopathology · 2026Article
- Associations between antenatal corticosteroids and neonatal morbidities in a prospective cohort: role of course, timing, and gestational age.Frontiers in pediatrics · 2026Article
- Association Between Prenatal Air Pollution Exposure and Autism in Children: EPINED Study.Journal of autism and developmental disorders · 2025Article
- Mapping Fetal Brain Development of 10 Weeks' Gestational Age with 9.4T Postmortem MRI and Histologic Sections.AJNR. American journal of neuroradiology · 2025Article
- Analysis of automatic fetal intracranial volume (ICV) measurement based on the optimized ultrasound Smart ICV method at 16-34 weeks of gestation.Quantitative imaging in medicine and surgery · 2024Article
- Systematic review and meta-analysis of MRI-based sex differences in the human fetal brain.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeRecent advances in fetal MR imaging technology have enabled acquisition of diagnostic images in the early second trimester. Interpretation of these examinations is limited by a lack of familiarity with the developmental changes that occur during these early stages of growth. This study aimed to characterize normal fetal brain growth between the 12th and 20th weeks of gestational age. MATERIALS AND
methodsThis study was conducted as an observational retrospective analysis. Data were obtained from a tertiary care center's PACS database. All fetuses included had late fetal MR imaging (>20 weeks) or postnatal MR imaging, which confirmed normality. Each MR image was manually segmented, with ROIs placed to calculate the volume of the supratentorial parenchyma, brainstem, cerebellum, ventricular CSF, and extra-axial CSF. A linear regression analysis was used to evaluate gestational age as a predictor of the volume of each structure.
resultsThirty-one subjects with a mean gestational age of 17.23 weeks (range, 12-19 weeks) were studied. There was a positive, significant association between gestational age and intracranial, supratentorial parenchyma; brainstem cerebellum; intraventricular CSF; and extra-axial CSF volumes (
conclusionsThis study demonstrates distinct trajectories for the major compartments of the fetal brain in the early second trimester. The fastest growth rates were observed in the supratentorial brain and extra-axial CSF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.