Evidence map›Paper›PMID 37972892›Full record

ArticleOphthalmology. Retina2024

In-Depth Analysis of Preoperative OCT Markers as Prognostic Factors for Lamellar Macular Holes and Epiretinal Membrane Foveoschisis.

Mya Abousy, Laura E Drew-Bear, Alison Gibbons, Nathan Pan-Doh, Ximin Li, James T Handa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Current Topics in OCT Applications in Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mya AbousyBascom Palmer Eye Institute, University of Miami, Miami, Florida; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Laura E Drew-BearWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; University of Missouri-Kansas City Department of Ophthalmology, Kansas City, Missouri.
Alison GibbonsWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nathan Pan-DohWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ximin LiWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
James T HandaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: jthanda@jhmi.edu.
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
NEI NIH HHS P30 EY001765
6 · The paper itself

Abstract

objectiveTo identify preoperative OCT markers that correlate with postoperative visual acuity (VA) changes in eyes with lamellar macular hole (LMH) and epiretinal membrane foveoschisis (ERMF) after pars plana vitrectomy (PPV).

designCross-sectional retrospective study. SUBJECTS: Patients seen at the Wilmer Eye Institute between 2011 and 2021 with an International Classification of Diseases, Ninth Revision, or International Classification of Diseases, 10th Revision, code for "macular hole" that underwent PPV, and demonstrated all OCT criteria present for either LMH or ERMF based on the Hubschman et al (2020) classification.

methodsOCT markers including hole dimensions, retinal layer continuity, and ellipsoid zone (EZ) convexity and pixelated intensity were quantified. Visual acuity immediately before PPV and at the last follow-up date available were both recorded.

main outcome measuresPreoperative OCT variables that are correlated with postoperative changes in VA.

resultsForty-two eyes from 42 patients with LMH (n = 11) and ERMF (n = 31) that underwent PPV were identified. Visual acuity in the ERMF cohort significantly improved at last follow-up compared with preoperative VA (P < 0.001), whereas VA in the LMH cohort did not (P = 0.14). In the LMH cohort, retinal layer continuity at the hole edge was positively correlated with change in VA at final follow-up, whereas hole height was negatively correlated with VA. In the ERMF cohort, preoperative VA was negatively correlated with change in VA at final follow-up.

conclusionsRetinal layer continuity at the hole and hole height are novel preoperative markers that predict postoperative VA change in LMH. After identifying the type of macular lesion, surgeons should consider using these preoperative OCT markers when counseling patients on potential postoperative VA outcomes and when managing patient expectations. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Epiretinal MembraneRetinal PerforationsRetinoschisisTomography, Optical CoherenceVisual AcuityVitrectomyAgedCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPreoperative PeriodPrognosisRetrospective StudiesDegenerativeEpiretinal membrane foveoschisisLamellar macular holeLow visionOptical coherence tomographyPars plana vitrectomyTractionalVision loss

Identifiers

PMID37972892
PMCPMC11070309
OpenAlexW4388673127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.