Evidence map›Paper›PMID 37972769›Full record

ArticleToxicology and applied pharmacology2023

Up-regulation of RNA m

Zhishan Wang, Mohammad Burhan Uddin, Po-Shun Wang, Zulong Liu, David Barzideh, Chengfeng Yang

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  6. Review
  7. Emerging roles of NHeliyon · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhishan WangStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA. Electronic address: zhishan.wang@stonybrook.edu.
Mohammad Burhan UddinDepartment of Toxicology and Cancer Biology, University of Kentucky School of Medicine, Lexington, KY, USA.
Po-Shun WangStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
Zulong LiuStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
David BarzidehStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
Chengfeng YangStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Stony Brook University · USUniversity of Kentucky · US

Funding

Dysregulations of functional RNA modifications and hexavalent chromium lungcarcinogenesisR01ES032787 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Chengfeng Yang · 2022 to 2026
$2.1M
MECHANISM OF HEXAVALENT CHROMIUM CARCINOGENESIS ROLE OF LONG NON-CODING RNA DYSREGULATIONR01ES029942 · NIEHS · UNIVERSITY OF KENTUCKY · PI YANG, CHENGFENG · 2019 to 2023
$1.8M
EPIGENETIC MECHANISM OF THE SYNERGISTIC TUMORIGENIC EFFECT OF ARSENICAND BENZO[A]PYRENE CO-EXPOSURER01ES028256 · NIEHS · UNIVERSITY OF KENTUCKY · PI WANG, ZHISHAN · 2018 to 2022
$1.8M
THE EPIGENETIC MECHANISM OF HEXAVALENT CHROMIUM CARCINOGENESISR01ES026151 · NIEHS · UNIVERSITY OF KENTUCKY · PI YANG, CHENGFENG · 2016 to 2020
$1.7M
MGMT DOWN-REGULATION IN THE CARCINOGENICITY OF HEXAVALENT CHROMIUMR01ES029496 · NIEHS · UNIVERSITY OF KENTUCKY · PI WANG, ZHISHAN · 2019 to 2023
$1.7M
NIEHS NIH HHS R01 ES026151NIEHS NIH HHS R01 ES028256NIEHS NIH HHS R01 ES029496NIEHS NIH HHS R01 ES029942NIEHS NIH HHS R01 ES032787
6 · The paper itself

Abstract

While arsenic or BaP alone exposure can cause lung cancer, studies showed that arsenic plus BaP co-exposure displays a significantly stronger lung tumorigenic effect. However, the underlying mechanism has not been well understood. Studies showed that RNA molecules are chemically modified. The most frequently occurring RNA modification in eukaryotic messenger RNAs is the N6-methyladenosine (m

Indexed as

ArsenicMethyltransferasesNeoplastic Stem CellsRNAAnimalsBenzo(a)pyreneCarcinogenesisHumansMiceUp-RegulationArsenicBenzo(a)pyreneMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseRNAArsenicBenzo(a)pyrene (BaP)EpitranscriptomeMETTL3Mixture exposureRNA m(6)A modification

Identifiers

PMID37972769
PMCPMC11375689
OpenAlexW4388680514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.