Evidence map›Paper›PMID 37972540›Full record

ReviewPhysics in medicine and biology2023

Review and recommendations on deformable image registration uncertainties for radiotherapy applications.

Lena Nenoff, Florian Amstutz, Martina Murr, Ben Archibald-Heeren, Marco Fusella, Mohammad Hussein, Wolfgang Lechner, Ye Zhang, Greg Sharp, Eliana Vasquez Osorio

Abstract readReview
In one paragraph

Review in Physics in medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  9. [A reweighted graph matching-based algorithm for automatic extraction of corresponding landmarks in medical images].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
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  10. Review
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  16. A dedicated institutional clinical workflow and peer-review meeting for reirradiation.Technical innovations & patient support in radiation oncology · 2026
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  20. Accuracy of reirradiation dose constraints for the mandible and carotids.Physics and imaging in radiation oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lena NenoffDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States of America.ORCID 0000-0002-7468-835X
Florian AmstutzDepartment of Physics, ETH Zurich, Switzerland.ORCID 0000-0003-1416-8093
Martina MurrSection for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Germany.
Ben Archibald-HeerenIcon Cancer Centres, Sydney, NSW, Australia.ORCID 0000-0001-9013-6048
Marco FusellaDepartment of Radiation Oncology, Abano Terme Hospital, Italy.ORCID 0000-0002-5361-8387
Mohammad HusseinMetrology for Medical Physics, National Physical Laboratory, Teddington, United Kingdom.
Wolfgang LechnerDepartment of Radiation Oncology, Medical University of Vienna, Austria.ORCID 0000-0001-9211-7510
Ye ZhangCenter for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.ORCID 0000-0003-1608-4467
Greg SharpDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States of America.
Eliana Vasquez OsorioDivision of Cancer Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0003-0741-994X

Funding

Fast Individualized Delivery Adaptation in Proton TherapyR01CA229178 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PAGANETTI, HARALD · 2019 to 2023
$1.5M
NCI NIH HHS R01 CA229178
6 · The paper itself

Abstract

Deformable image registration (DIR) is a versatile tool used in many applications in radiotherapy (RT). DIR algorithms have been implemented in many commercial treatment planning systems providing accessible and easy-to-use solutions. However, the geometric uncertainty of DIR can be large and difficult to quantify, resulting in barriers to clinical practice. Currently, there is no agreement in the RT community on how to quantify these uncertainties and determine thresholds that distinguish a good DIR result from a poor one. This review summarises the current literature on sources of DIR uncertainties and their impact on RT applications. Recommendations are provided on how to handle these uncertainties for patient-specific use, commissioning, and research. Recommendations are also provided for developers and vendors to help users to understand DIR uncertainties and make the application of DIR in RT safer and more reliable.

Indexed as

Image Processing, Computer-AssistedRadiotherapy Planning, Computer-AssistedAlgorithmsHumansRadiotherapy DosageUncertaintydeformable image registrationDIR uncertaintydose accumulationimage deformationmappingradiotherapystrucutre propagation

Identifiers

PMID37972540
PMCPMC10725576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.