ArticleJournal of medicinal chemistry2023
Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.
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Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6.International journal of molecular sciences · 2026Review
- HDAC11 as a potential therapeutic target for Alzheimer's disease.Drug discovery today · 2026Review
- Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors.ACS pharmacology & translational science · 2026Review
- Recent Insights into the Creation of Histone Deacetylase Inhibitors for the Treatment of Human Diseases.International journal of molecular sciences · 2025Review
- The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.Anesthesia and analgesia · 2025Article
- Development of Carbon-11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma-1 Receptor Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Histone Deacetylase Inhibition in Alzheimer's Disease: Molecular Mechanisms, Therapeutic Potential, and Future Perspectives.Current topics in medicinal chemistry · 2025Review
- Distribution and diversity of classical deacylases in bacteria.Nature communications · 2024Article
- Article
- Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Ping BaiDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Yan LiuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Liuyue YangDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Weihua DingDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0001-8840-2917
Prasenjit MondalGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-0767-449X
Na SangDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Gang LiuChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
Xiaoxia LuChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
Thanh Tu HoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-1582-8404
Yanting ZhouDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Rui WuDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Vishal C BirarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Moses Q WilksGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-0255-2701
Can ZhangGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-4340-5118
Weimin LiDepartment of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.ORCID 0000-0003-0985-0311
Shiqian ShenDepartment of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-2076-4193
Harvard University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNMassachusetts General Hospital · USChinese Academy of Sciences · CNCornell University · USHoward Hughes Medical Institute · US
Funding
Gut Microbiota Influences Postoperative Cognitive Dysfunction through Indole-3-Propionic AcidR35GM128692 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2018 to 2022
$2.2MGut Microbiota Underlies the Heterogeneity of Aging Brain's Susceptibility to Postoperative DeliriumRF1AG070141 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN, WANG, CHANGNING · 2021 to 2021
$1.7MInhibiting RIPK1 with Necrostatin-1 for Safe and Effective Pain TreatmentR61NS126029 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HOULE, TIMOTHY T, SHEN, SHIQIAN · 2022 to 2022
$1.6MDevelopment and Validation of a Clinically Relevant Animal Pain ModelR61NS116423 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SHEN, SHIQIAN · 2020 to 2020
$420kNIA NIH HHS RF1 AG070141NIGMS NIH HHS R35 GM128692NINDS NIH HHS R61 NS116423NINDS NIH HHS R61 NS126029
Abstract
Recent studies have shown that the epigenetic protein histone deacetylase 11 (HDAC11) is highly expressed in the brain and critically modulates neuroimmune functions, making it a potential therapeutic target for neurological disorders. Herein, we report the development of PB94, which is a novel HDAC11 inhibitor. PB94 exhibited potency and selectivity against HDAC11 with IC
Indexed as
NeuralgiaNeuroinflammatory DiseasesAnimalsBrainHistone Deacetylase InhibitorsHistone DeacetylasesMiceHistone Deacetylase InhibitorsHistone Deacetylases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.