ArticleAmerican journal of respiratory and critical care medicine2024
Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model.
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Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Sympathetic signaling activation alleviated acute respiratory distress syndrome via the HDC/SLC7A11 axis in lipopolysaccharide-induced macrophages.Cell death discovery · 2026Article
- CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026Review
- Neutrophil store-operated CaJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- Article
- Is the SPLUNC1-Orai1 axis a critical determinant of lung health?Biochemical Society transactions · 2025Review
- Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Dexmedetomidine administration reduced mortality in patients with acute respiratory distress syndrome: a propensity score-matched cohort analysis.Frontiers in medicine · 2025Article
- Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells.bioRxiv : the preprint server for biology · 2024Article
- ORAI CaBiomolecules · 2024Review
- Macrophage SPLUNC-ing Clears Bacteria in the Lung.American journal of respiratory and critical care medicine · 2024Article
- Focus on the role of calcium signaling in ferroptosis: a potential therapeutic strategy for sepsis-induced acute lung injury.Frontiers in medicine · 2024Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Saira AhmadDepartment of Cell Biology and Physiology.
Joe A WrennallDepartment of Cell Biology and Physiology.
Alexandra S GoriounovaDepartment of Pharmacology.
Malika SekhriDepartment of Cell Biology and Physiology.
Jason A IskarpatyotiEldec Pharmaceuticals, Chapel Hill, North Carolina.
Arunava GhoshDepartment of Cell Biology and Physiology.
Sabri H AbdelwahabDepartment of Cell Biology and Physiology.
Alexis VoellerDepartment of Cell Biology and Physiology.
Mani RaiDepartment of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina; and.
Rahul Y MahidaBirmingham Acute Care Research Group, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-1100-8684
Krzysztof KrajewskiDepartment of Biochemistry and Biophysics, and.
Diane M IgnarEldec Pharmaceuticals, Chapel Hill, North Carolina.
Alon GreenbaumDepartment of Biomedical Engineering, North Carolina State University, Raleigh, North Carolina; and.
Timothy P MoranDepartment of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephen L TilleyDepartment of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
David R ThickettBirmingham Acute Care Research Group, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-5456-6080
M Flori SassanoDepartment of Cell Biology and Physiology.
Robert TarranDepartment of Cell Biology and Physiology.ORCID 0000-0002-8598-2642
University of North Carolina at Chapel Hill · USLung Institute · USNorth Carolina State University · USUniversity of Birmingham · GBVascular Pharmaceuticals (United States) · USUnited States University · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MVector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MTRAINING IN RESPIRATORY AND ENVIRONMENTAL MEDICINET32HL007106 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, DOERSCHUK, CLAIRE M · 1985 to 2021
$7.3MELD607 Orai1 Antagonist Increases Bacterial Clearance from the LungR42AI155107 · NIAID · ELDEC PHARMACEUTICALS, INC. · PI TARRAN, ROBERT · 2020 to 2022
$2.3MNovel Strategies to Clear Bacteria from the CF LungR44HL165964 · NHLBI · ELDEC PHARMACEUTICALS, INC. · PI AHMAD, SAIRA · 2022 to 2023
$2.1MThe role of neuropilin-2 in regulating environmental airways injuryK08ES029118 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORAN, TIMOTHY · 2019 to 2021
$635kPeptide therapies for treating CF lung inflammationR43HL144290 · NHLBI · ELDEC PHARMACEUTICALS, INC. · PI SHEA, RICHARD JOSEPH · 2018 to 2018
$225kMedical Research Council MR/N021185/1Medical Research Council MR/X000338/1NCI NIH HHS P30 CA016086NHLBI NIH HHS R43 HL144290NHLBI NIH HHS R44 HL165964NHLBI NIH HHS T32 HL007106NIAID NIH HHS R42 AI155107NIDDK NIH HHS P30 DK065988NIEHS NIH HHS K08 ES029118
Abstract
PubMed holds no abstract for this paper.
Indexed as
Methicillin-Resistant Staphylococcus aureusPneumonia, BacterialRespiratory Distress SyndromeAnimalsCalciumCalcium ChannelsCalcium SignalingHEK293 CellsHumansInflammationLungMiceORAI1 ProteinCalciumCalcium ChannelsORAI1 ProteinOrai1 protein, mouseARDSICRACneutrophiliapeptidepneumonia
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.