Evidence map›Paper›PMID 37972337›Full record

ArticleJCO precision oncology2023

Amplification of Wild-Type

Malini M Gandhi, Biagio Ricciuti, Guilherme Harada, Matteo Repetto, Melissa S Gildenberg, Ankit Singh, Yvonne Y Li, Andréanne Gagné, Xinan Wang, Ayal Aizer and 11 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in JCO precision oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. AccurateInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Cancers · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Malini M GandhiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-8006-4148
Biagio RicciutiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-0651-2678
Guilherme HaradaMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.ORCID 0000-0003-4012-3251
Matteo RepettoMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.
Melissa S GildenbergDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0003-0358-0381
Ankit SinghCenter for Integrated Diagnostics, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-6522-9223
Yvonne Y LiDepartment of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA.
Andréanne GagnéDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-3833-4159
Xinan WangHarvard School of Public Health, Boston, MA.ORCID 0000-0001-5236-1105
Ayal AizerDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-8941-188X
Kelly FitzgeraldDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-6698-5840
Mizuki NishinoDepartment of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-0275-0502
Joao AlessiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-8072-5946
Federica PecciLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.
Alessandro Di FedericoLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0001-8877-4315
Adam FischDepartment of Pathology, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-4742-8165
Alexander DrilonMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.ORCID 0000-0001-6806-9061
Valentina NardiDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
Lynette ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-9532-9735
Mark M AwadLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0003-0928-5244
Julia RotowLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.
Dana-Farber Cancer Institute · USBrigham and Women's Hospital · USMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USHarvard University · USBroad Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Integration of Imaging and Circulating Plasma Cell-Free DNA Sequencing Using MSK-ACCESS to Monitor Treatment Response and Predict Progression in Patients With Multiple Cancers on Targeted TherapyR01CA273224 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Michael F. Berger, Alexander Drilon · 2022 to 2026
$3.6M
Predicting sensitivity and resistance in RET-driven cancersR01CA251591 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DRILON, ALEXANDER · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA251591NCI NIH HHS R01 CA273224
6 · The paper itself

Abstract

purpose

methodsIn two institutional cohorts of patients with solid cancers from the Dana-Farber Cancer Institute (DFCI) and Memorial Sloan Kettering Cancer Center (MSKCC) whose tumors underwent next-generation sequencing (NGS), the frequency and clinicopathologic features of wild-type

resultsThe frequency of wild-type

conclusionAmplification of wild-type

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAgedHumansMaleMutationNeoplasm Recurrence, LocalProto-Oncogene Proteins c-retPyrazolesPyridinesProto-Oncogene Proteins c-retPyrazolesPyridinesRET protein, humanselpercatinib

Identifiers

PMID37972337
PMCPMC10681403
OpenAlexW4388737775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.