ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024
Vaccine Effectiveness Against Pediatric Influenza-A-Associated Urgent Care, Emergency Department, and Hospital Encounters During the 2022-2023 Season: VISION Network.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Influenza vaccination in children with underlying conditions: affirming effectiveness and confronting gaps.Translational pediatrics · 2026Article
- Influenza Vaccination Trends Among Children and Adolescents, 2017-2023.JAMA network open · 2026Article
- Influenza Vaccine and Associated Infection and Death in California, 2024 to 2025.JAMA network open · 2026Article
- Modest protection from vaccination against influenza A(H3N2) subclade K, Beijing, China, 2025/26 season.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Next-generation intranasal influenza vaccines: mechanisms, platforms, and translational progress.Frontiers in immunology · 2026Review
- Data science for pediatric infectious disease: utilizing COVID-19 as a model.Current opinion in infectious diseases · 2025Review
- Characteristics of children with influenza admitted to a pediatric hospital in Greece during the 2022/2023 and 2023/2024 seasons.European journal of pediatrics · 2025Observational
- Cost-effectiveness of vaccinating children at school - A commentary.Journal of family & child health · 2025Article
- Article
- Increasing child vaccination coverage can reduce influenza cases across age groups: An agent-based modeling study.The Journal of infection · 2025Article
- Family matters: influenza vaccination uptake and associated factors in children aged 6 months-6 years.Frontiers in public health · 2025Article
- Practices and barriers associated with administration of influenza (flu) vaccination among the general population of UAE.Journal of education and health promotion · 2025Article
- Population-Based Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza Infection in Southern China, 2023-2024 Season.Open forum infectious diseases · 2024Article
- Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022-April 2023.Influenza and other respiratory viruses · 2024Article
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Authors and funding
29 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundDuring the 2022-2023 influenza season, the United States experienced the highest influenza-associated pediatric hospitalization rate since 2010-2011. Influenza A/H3N2 infections were predominant.
methodsWe analyzed acute respiratory illness (ARI)-associated emergency department or urgent care (ED/UC) encounters or hospitalizations at 3 health systems among children and adolescents aged 6 months-17 years who had influenza molecular testing during October 2022-March 2023. We estimated influenza A vaccine effectiveness (VE) using a test-negative approach. The odds of vaccination among influenza-A-positive cases and influenza-negative controls were compared after adjusting for confounders and applying inverse-propensity-to-be-vaccinated weights. We developed overall and age-stratified VE models.
resultsOverall, 13 547 of 44 787 (30.2%) eligible ED/UC encounters and 263 of 1862 (14.1%) hospitalizations were influenza-A-positive cases. Among ED/UC patients, 15.2% of influenza-positive versus 27.1% of influenza-negative patients were vaccinated; VE was 48% (95% confidence interval [CI], 44-52%) overall, 53% (95% CI, 47-58%) among children aged 6 months-4 years, and 38% (95% CI, 30-45%) among those aged 9-17 years. Among hospitalizations, 17.5% of influenza-positive versus 33.4% of influenza-negative patients were vaccinated; VE was 40% (95% CI, 6-61%) overall, 56% (95% CI, 23-75%) among children ages 6 months-4 years, and 46% (95% CI, 2-70%) among those 5-17 years.
conclusionsDuring the 2022-2023 influenza season, vaccination reduced the risk of influenza-associated ED/UC encounters and hospitalizations by almost half (overall VE, 40-48%). Influenza vaccination is a critical tool to prevent moderate-to-severe influenza illness in children and adolescents.
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