Evidence map›Paper›PMID 37972231›Full record

ArticleThe Journal of infectious diseases2024

Prosurvival Pathway Protects From Clostridioides difficile Toxin-Mediated Cell Death.

William Tornel, Ishrya Sharma, Hiba Osmani, Shannon Moonah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. A single amino acid substitution determines susceptibility ofFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

William TornelDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Ishrya SharmaDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Hiba OsmaniDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Shannon MoonahDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.ORCID 0000-0001-7376-5125
University of Virginia Health System · US

Funding

CD74 and Wound HealingR01DK131313 · NIDDK · UNIVERSITY OF VIRGINIA · PI Shannon Moonah · 2022 to 2026
$1.8M
Hartwell FoundationNIDDK NIH HHS R01 DK131313NIH HHS R01DK131313
6 · The paper itself

Abstract

There is an urgent need for new nonantibiotic-based treatment strategies for Clostridioides difficile infection. C. difficile toxin B (TcdB) is a virulent factor that is essential for causing disease. Here, we investigated whether a survival-signaling pathway could protect against TcdB. We found significant increase in caspase-3 apoptotic activity in intestinal epithelial cells of mice exposed to TcdB. Subsequently, activation of the MIF-CD74-Akt prosurvival signaling pathway blocked TcdB-induced caspase-3 activity and intestinal epithelial cell death. This brief report provides proof-of-concept that targeting prosurvival pathways may represent a unique antibiotic-independent strategy for protecting against C. difficile toxin-mediated cell death.

Indexed as

ApoptosisBacterial ProteinsBacterial ToxinsClostridioides difficileSignal TransductionAnimalsCaspase 3Cell DeathClostridium InfectionsEpithelial CellsMiceMice, Inbred C57BLProto-Oncogene Proteins c-aktBacterial ProteinsBacterial ToxinsCaspase 3Proto-Oncogene Proteins c-aktAktapoptosiscaspaseC difficilecell deathcell survivaltoxin

Identifiers

PMID37972231
PMCPMC11095527
OpenAlexW4388720491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.