Evidence map›Paper›PMID 37972127›Full record

ArticlePloS one2023

Campomanesia adamantium O Berg. fruit, native to Brazil, can protect against oxidative stress and promote longevity.

Laura Costa Alves de Araújo, Natasha Rios Leite, Paola Dos Santos da Rocha, Debora da Silva Baldivia, Danielle Araujo Agarrayua, Daiana Silva Ávila, Denise Brentan da Silva, Carlos Alexandre Carollo, Jaqueline Ferreira Campos, Kely de Picoli Souza and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Food science & nutrition · 2025
    Article
  4. Article
  5. Lipid-Lowering and Anti-Inflammatory Effects ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Laura Costa Alves de AraújoResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Natasha Rios LeiteResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Paola Dos Santos da RochaResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Debora da Silva BaldiviaResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Danielle Araujo AgarrayuaResearch Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil.
Daiana Silva ÁvilaResearch Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil.
Denise Brentan da SilvaLaboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Carlos Alexandre CarolloLaboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Jaqueline Ferreira CamposResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Kely de Picoli SouzaResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Edson Lucas Dos SantosResearch Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.ORCID 0000-0002-6557-7914
Universidade Federal da Grande Dourados · BRUniversidade Federal de Mato Grosso do Sul · BRUniversidade Federal do Pampa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Campomanesia adamantium O. Berg. is a fruit tree species native to the Brazilian Cerrado biome whose fruits are consumed raw by the population. The present study determined the chemical composition of the C. adamantium fruit pulp (FPCA) and investigated its in vitro antioxidant potential and its biological effects in a Caenorhabditis elegans model. The chemical profile obtained by LC-DAD-MS identified 27 compounds, including phenolic compounds, flavonoids, and organic carboxylic acids, in addition to antioxidant lipophilic pigments and ascorbic acid. The in vitro antioxidant activity was analysed by the radical scavenging method. In vivo, FPCA showed no acute reproductive or locomotor toxicity. It promoted protection against thermal and oxidative stress and increased the lifespan of C. elegans. It also upregulated the antioxidant enzymes superoxide dismutase and glutathione S-transferase and activated the transcription factor DAF-16. These results provide unprecedented in vitro and in vivo evidence for the potential functional use of FPCA in the prevention of oxidative stress and promotion of longevity.

Indexed as

Caenorhabditis elegans ProteinsMyrtaceaeAnimalsAntioxidantsBrazilCaenorhabditis elegansFruitLongevityOxidative Stressp-ChloroamphetaminePlant Extracts2-amino-1-(4-chlorophenyl)-3-fluoropropaneAntioxidantsCaenorhabditis elegans Proteinsp-ChloroamphetaminePlant Extracts

Identifiers

PMID37972127
PMCPMC10653513
OpenAlexW4388728311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.