ArticleMMWR. Morbidity and mortality weekly report2023
Vital Signs: Missed Opportunities for Preventing Congenital Syphilis - United States, 2022.
Article in MMWR. Morbidity and mortality weekly report, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Factors influencing implementation of point-of-care tests for maternal and newborn screening and diagnosis in low-resource settings: a systematic review.BMC global and public health · 2026Pooled it
- Factors influencing adult and adolescent completion of treatment for late syphilis: a mixed methods systematic review.Bulletin of the World Health Organization · 2025Pooled it
- Gaps in Syphilis Screening Among Pregnant Women in North Carolina.Sexually transmitted diseases · 2026Article
- Emergency Department Syphilis Screening: Insights from a National Stakeholder Convening.Journal of the American College of Emergency Physicians open · 2026Article
- Re-Emergence of the Great Mimicker: Congenital Syphilis in a Low Prevalence Setting.Infectious disease reports · 2026Article
- Maternal Health Outcomes Associated With Syphilis Infection During Pregnancy: Evidence From a Large US All-Payer Hospital-Centered Administrative Database.Open forum infectious diseases · 2026Article
- Elimination of congenital syphilis: a nationwide register-based study, Denmark, 2010 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Timeliness of Treatment Initiation Among US Syphilis Cases in 2023.Sexually transmitted diseases · 2026Article
- Utilization and Performance of a Rapid Treponemal Antibody Test for Diagnosis of Syphilis in a High-Risk Population at an Urban County Hospital.Sexually transmitted diseases · 2026Article
- The Congenital Syphilis Surge: Clinician Lessons to Turn the Rising Tide.Advances in pediatrics · 2026Review
- Preventing Congenital Syphilis Through Prenatal Care: Qualitative Findings from a Pilot Clinical Program.Sexually transmitted diseases · 2026Article
- Prenatal characteristics and factors contributing to congenital syphilis: A descriptive analysis of cases reported to the Canadian Paediatric Surveillance Program June 2021 through May 2023.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Strengthening Prevention and Treatment of HIV, Viral Hepatitis, Sexually Transmitted Infections, and Tuberculosis Among Women Who Are Justice System-Involved: CDC Recommendations and Resources.Journal of women's health (2002) · 2026Article
- Healthcare Professionals' Perspectives on the Direct Referral Pathway for Syphilis Management in Western Sydney.Archives of sexual behavior · 2026Article
- Uptake of prenatal syphilis screening and its determinants in Ontario, Canada: a population-based retrospective cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Supply Chain Vulnerabilities in First-Line Treatments for Sexually Transmitted Infections: Implications for U.S. Public Health Preparedness.medRxiv : the preprint server for health sciences · 2026Article
- Characteristics Associated With Breakthrough Congenital Syphilis in Florida and Arizona, 2018-2022.Sexually transmitted diseases · 2026Article
- Congenital syphilis in Portugal, 2015-2024: Temporal-spatial characterization and gaps in prevention of vertical transmission.Epidemiology and infection · 2026Article
- Article
- Trends in Syphilis Partner Services Outcomes Among Women in 8 US Jurisdictions, 2015-2022.Sexually transmitted diseases · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Congenital syphilis cases in the United States increased 755% during 2012-2021. Syphilis during pregnancy can lead to stillbirth, miscarriage, infant death, and maternal and infant morbidity; these outcomes can be prevented through appropriate screening and treatment. Methods: A cascading framework was used to identify and classify missed opportunities to prevent congenital syphilis among cases reported to CDC in 2022 through the National Notifiable Diseases Surveillance System. Data on testing and treatment during pregnancy and clinical manifestations present in the newborn were used to identify missed opportunities to prevent congenital syphilis. Results: In 2022, a total of 3,761 cases of congenital syphilis in the United States were reported to CDC, including 231 (6%) stillbirths and 51 (1%) infant deaths. Lack of timely testing and adequate treatment during pregnancy contributed to 88% of cases of congenital syphilis. Testing and treatment gaps were present in the majority of cases across all races, ethnicities, and U.S. Census Bureau regions. Conclusions and implications for public health practice: Addressing missed opportunities for prevention, primarily timely testing and appropriate treatment of syphilis during pregnancy, is important for reversing congenital syphilis trends in the United States. Implementing tailored strategies addressing missed opportunities at the local and national levels could substantially reduce congenital syphilis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.