Evidence map›Paper›PMID 37971861›Full record

ArticleNeuropsychology2024

Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.

Roos J Jutten, Rebecca E Amariglio, Paul Maruff, Michael J Properzi, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Kathryn V Papp

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Roos J JuttenDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.ORCID 0000-0002-3712-4790
Rebecca E AmariglioDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Paul MaruffCogstate Ltd.
Michael J ProperziDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Dorene M RentzDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Keith A JohnsonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Kathryn V PappDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School.
Harvard University · US

Funding

Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Hyun-Sik Yang · 2010 to 2026
$50.2M
Optimizing semantic memory measures to detect tau- and amyloid- related cognitive changeK23AG053422 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI PAPP, KATHRYN VICTORIA · 2016 to 2020
$681k
Alzheimer's AssociationDutch Research CouncilNIA NIH HHS K23 AG053422NIA NIH HHS P01 AG036694
6 · The paper itself

Abstract

objectiveTo investigate whether intraindividual variability (IIV) in reaction time (RT) over monthly administered cognitive tasks is increased in cognitively unimpaired older adults who are at risk for cognitive decline, and whether this is independent of mean RT performance.

method

resultsAfter adjusting for mean RT, increased IIV on complex RT tasks was independently associated with worse EF performance (β = -0.10, 95% CI [-.16, -0.03],

conclusionsIncreased variability in monthly RT may reflect subtle EF deficits and provide unique information about short-term cognitive decline in preclinical Alzheimer's disease. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAmyloid beta-PeptidesCross-Sectional StudiesFemaleHumansMalePositron-Emission TomographyReaction Timetau ProteinsAmyloid beta-Peptidestau Proteins

Identifiers

PMID37971861
PMCPMC12184789
OpenAlexW4388734702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.