Evidence map›Paper›PMID 37971801›Full record

ArticleJMIR research protocols2023

Development of the ehive Digital Health App: Protocol for a Centralized Research Platform.

Robert P Hirten, Matteo Danieletto, Kyle Landell, Micol Zweig, Eddye Golden, Georgy Orlov, Jovita Rodrigues, Eugenia Alleva, Ipek Ensari, Erwin Bottinger and 3 more

Abstract read
In one paragraph

Article in JMIR research protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Daily Consistency Over Timing: Routine Formation and Population-Specific Opportunities in mHealth User Adherence.Extended abstracts on Human factors in computing systems. CHI Conference · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Robert P HirtenHenry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0002-7980-9368
Matteo DanielettoHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0002-5178-9182
Kyle LandellHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-5277-6888
Micol ZweigHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-8190-7197
Eddye GoldenHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0002-9818-5693
Georgy OrlovHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0009-0002-0210-7701
Jovita RodriguesHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0009-0006-9807-4324
Eugenia AllevaHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0003-3523-693X
Ipek EnsariHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-7745-8501
Erwin BottingerHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-6868-6676
Girish N NadkarniCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-6319-4314
Thomas J FuchsHasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0001-7603-8687
Zahi A FayadBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.ORCID https://orcid.org/0000-0002-3439-7347

Funding

COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Digital Biomarkers of Ulcerative Colitis FlareK23DK129835 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HIRTEN, ROBERT · 2021 to 2025
$812k
NIDDK NIH HHS K23 DK129835NIH HHS S10 OD026880NIH HHS S10 OD030463
6 · The paper itself

Abstract

backgroundThe increasing use of smartphones, wearables, and connected devices has enabled the increasing application of digital technologies for research. Remote digital study platforms comprise a patient-interfacing digital application that enables multimodal data collection from a mobile app and connected sources. They offer an opportunity to recruit at scale, acquire data longitudinally at a high frequency, and engage study participants at any time of the day in any place. Few published descriptions of centralized digital research platforms provide a framework for their development.

objectiveThis study aims to serve as a road map for those seeking to develop a centralized digital research platform. We describe the technical and functional aspects of the ehive app, the centralized digital research platform of the Hasso Plattner Institute for Digital Health at Mount Sinai Hospital, New York, New York. We then provide information about ongoing studies hosted on ehive, including usership statistics and data infrastructure. Finally, we discuss our experience with ehive in the broader context of the current landscape of digital health research platforms.

methodsThe ehive app is a multifaceted and patient-facing central digital research platform that permits the collection of e-consent for digital health studies. An overview of its development, its e-consent process, and the tools it uses for participant recruitment and retention are provided. Data integration with the platform and the infrastructure supporting its operations are discussed; furthermore, a description of its participant- and researcher-facing dashboard interfaces and the e-consent architecture is provided.

resultsThe ehive platform was launched in 2020 and has successfully hosted 8 studies, namely 6 observational studies and 2 clinical trials. Approximately 1484 participants downloaded the app across 36 states in the United States. The use of recruitment methods such as bulk messaging through the EPIC electronic health records and standard email portals enables broad recruitment. Light-touch engagement methods, used in an automated fashion through the platform, maintain high degrees of engagement and retention. The ehive platform demonstrates the successful deployment of a central digital research platform that can be modified across study designs.

conclusionsCentralized digital research platforms such as ehive provide a novel tool that allows investigators to expand their research beyond their institution, engage in large-scale longitudinal studies, and combine multimodal data streams. The ehive platform serves as a model for groups seeking to develop similar digital health research programs. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/49204.

Indexed as

centralized digital research platformdevelopmentdigital healthdigital studydigital technologieseHiveehive appframeworkmobile phonemultimodal data collectionresearch platformsmartphonewearable deviceswearables

Identifiers

PMID37971801
PMCPMC10690532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.