Evidence map›Paper›PMID 37971675›Full record

ArticleNano convergence2023

3D-printed wound dressing platform for protein administration based on alginate and zinc oxide tetrapods.

Philipp Schadte, Franziska Rademacher, Gerrit Andresen, Marie Hellfritzsch, Haoyi Qiu, Gregor Maschkowitz, Regine Gläser, Nina Heinemann, Daniel Drücke, Helmut Fickenscher and 4 more

Erratum issuedAbstract read
In one paragraph

Article in Nano convergence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Philipp SchadteFunctional Nanomaterials, Department for Material Science, Kiel University, Kiel, Germany.
Franziska RademacherDepartment of Dermatology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Gerrit AndresenInstitute for Infection Medicine, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Marie HellfritzschDepartment of Pharmaceutics and Biopharmaceutics, Kiel University, Kiel, Germany.
Haoyi QiuFunctional Nanomaterials, Department for Material Science, Kiel University, Kiel, Germany.
Gregor MaschkowitzInstitute for Infection Medicine, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Regine GläserDepartment of Dermatology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Nina HeinemannDepartment of Dermatology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Daniel DrückeDepartment of Reconstructive Surgery, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Helmut FickenscherInstitute for Infection Medicine, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Regina ScherließDepartment of Pharmaceutics and Biopharmaceutics, Kiel University, Kiel, Germany.
Jürgen HarderDepartment of Dermatology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.
Rainer AdelungFunctional Nanomaterials, Department for Material Science, Kiel University, Kiel, Germany. ra@tf.uni-kiel.de.
Leonard SiebertFunctional Nanomaterials, Department for Material Science, Kiel University, Kiel, Germany. lesi@tf.uni-kiel.de.ORCID http://orcid.org/0000-0001-5316-7240

Funding

Bundesministerium für Wirtschaft und Energie KK5010204MP1European Union, REACT-EU LPW-E/6.1.1/2263
6 · The paper itself

Abstract

Wound treatment requires a plethora of independent properties. Hydration, anti-bacterial properties, oxygenation and patient-specific drug delivery all contribute to the best possible wound healing. Three-dimensional (3D) printing has emerged as a set of techniques to realize individually adapted wound dressings with open porous structure from biomedically optimized materials. To include all the desired properties into the so-called bioinks is still challenging. In this work, a bioink system based on anti-bacterial zinc oxide tetrapods (t-ZnO) and biocompatible sodium alginate is presented. Additive manufacturing of these hydrogels with high t-ZnO content (up to 15 wt.%) could be realized. Additionally, protein adsorption on the t-ZnO particles was evaluated to test their suitability as carriers for active pharmaceutical ingredients (APIs). Open porous and closed cell printed wound dressings were tested for their cell and skin compatibility and anti-bacterial properties. In these categories, the open porous constructs exhibited protruding t-ZnO arms and proved to be anti-bacterial. Dermatological tests on ex vivo skin showed no negative influence of the alginate wound dressing on the skin, making this bioink an ideal carrier and evaluation platform for APIs in wound treatment and healing.

Indexed as

3D microcrystalsAntibacterial activityBiofabricationDermatologyNanomaterialsProtein decorationWound healingZinc oxide tetrapods

Identifiers

PMID37971675
PMCPMC10654273

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.