ArticleIndian journal of pediatrics2025
Prevalence and Predictors of Vitamin B12 Deficiency in Children with Severe Acute Malnutrition, and its Association with Development.
Article in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Vitamin B12 Deficiency: An Under-Addressed Community Health Problem.Indian journal of pediatrics · 2025Article
- Time for Another Leap for Improving Newborn Survival in India.Indian journal of pediatrics · 2024Article
- Carbohydrate Counting in Type 1 Diabetes: Look Beyond Glycemic Control.Indian journal of pediatrics · 2024Article
- Oral Antacid Use Is Negatively Associated with Serum Prealbumin Levels in Japanese Individuals Undergoing Health Checkups.Nutrients · 2024Article
- Article
- Point of Care Diagnostic Markers for Neonatal Sepsis.Indian journal of pediatrics · 2024Article
- Pre-Conceptional and Antenatal Care for Improved Newborn and Child Survival in India: A Review.Indian journal of pediatrics · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine the proportion of children with severe acute malnutrition (SAM) having vitamin B12 deficiency, its clinical predictors, and its association with development.
methodsIn this cross-sectional study, 100 children between 1 mo to 59 mo [mean (SD) age 17 (12.75) mo; 55 males], with diagnosis of SAM as per WHO criteria, were included. Serum vitamin B12, serum folate, and serum ferritin levels were measured by chemiluminescence immunometric assay method, while serum Homocysteine (Hcy) level was measured by enzymatic cycling method. Development assessment was done by Denver Development Screening Tool (DDST-II).
resultsThe mean (SD) serum vitamin B12 (cobalamin) levels were 296.52 (246.95) pg/mL; 45% children were vitamin B12 deficient (<203 pg/mL). Hyperhomocysteinemia (>14 µmol/L) was present in 39 (39%), and among these 69% (27/39) children had concomitant low serum vitamin B12 levels. Severe anemia and hypoproteinemia were significantly and independently associated with vitamin B12 deficiency [aOR (95% CI) 3.22 (1.13, 10) and 10 (1.66, 58.82), respectively]. Out of 45 children who were vitamin B12 deficient, 93%, 87%, 62% and 80% had gross motor, fine-motor, language and adaptive-cognitive delay, respectively. Vitamin B12 level was significantly associated (P <0.001) with developmental delay.
conclusionsThere is a high prevalence of vitamin B12 deficiency in children with SAM, which is also associated with development delay across all domains (except language) in these children.
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