Evidence map›Paper›PMID 37971504›Full record

Trial reportDiabetologia2024

Habitual carbohydrate intake is not correlated with circulating β-hydroxybutyrate levels in pregnant women with overweight and obesity at 28 weeks' gestation.

Helen L Tanner, Hui Ting Ng, Grace Murphy, Helen L Barrett, Leonie K Callaway, H David McIntyre, Marloes Dekker Nitert

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06355154 (Effects of Moderate Carbohydrate Consumption on Metabolic and Obstetric Outcomes in Pregnant Women With Insulin-treated Diabetes- A Randomized Controlled Trial), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06355154 narecruitingnot on this map

Effects of Moderate Carbohydrate Consumption on Metabolic and Obstetric Outcomes in Pregnant Women With Insulin-treated Diabetes- A Randomized Controlled Trial

TypeinterventionalSponsorHadassah Medical OrganizationRan2024 to 2028Enrolled120ConditionsDiabetes in PregnancyArmsNutritional intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Helen L TannerDepartment of Obstetric Medicine, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Herston, QLD, Australia.
Hui Ting NgSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Grace MurphySchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Helen L BarrettDepartment of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0001-7141-2086
Leonie K CallawayDepartment of Obstetric Medicine, Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Herston, QLD, Australia.
H David McIntyreMater Clinical Unit, Faculty of Medicine, The University of Queensland, South Brisbane, QLD, Australia.
Marloes Dekker NitertSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. m.dekker@uq.edu.au.ORCID 0000-0002-1909-8920
The University of Queensland · AUMater Health Services · AURoyal Brisbane and Women's Hospital · AURoyal Women's Hospital · AUUNSW Sydney · AU

Funding

National Health and Medical Research Council APP1028575
6 · The paper itself

Abstract

aims/hypothesisPregnant women are advised to consume a minimum of 175 g per day of carbohydrate to meet maternal and fetal brain glucose requirements. This recommendation comes from a theoretical calculation of carbohydrate requirements in pregnancy, rather than from clinical data. This study aimed to determine whether fasting maternal ketone levels are associated with habitual carbohydrate intake in a subset of participants of the Study of PRobiotics IN Gestational diabetes (SPRING) randomised controlled trial.

methodsFood frequency questionnaires on dietary intake during pregnancy were completed by pregnant women with overweight or obesity at 28 weeks' gestation (considering their intake from the beginning of pregnancy). Dietary intake from early pregnancy through to 28 weeks was analysed for macronutrient intake. At the same time, overnight fasting serum samples were obtained and analysed for metabolic parameters including serum β-hydroxybutyrate, OGTTs, insulin and C-peptide.

resultsFasting serum β-hydroxybutyrate levels amongst 108 women (mean BMI 34.7 ± 6.3 kg/m CONCLUSIONS/

interpretationFasting serum β-hydroxybutyrate levels are not associated with habitual carbohydrate intake at 28 weeks' gestation in pregnant women with overweight and obesity.

Indexed as

Diabetes, GestationalOverweight3-Hydroxybutyric AcidBlood GlucoseCarbohydratesFemaleGlucoseHumansObesityPregnancyPregnant People3-Hydroxybutyric AcidBlood GlucoseCarbohydratesGlucoseCarbohydrate intakeGestational diabetes mellitusGlucoseInsulinKetonesPregnancy

Identifiers

PMID37971504
PMCPMC10789657
OpenAlexW4388731549

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.