Evidence map›Paper›PMID 37971493›Full record

ArticleMicrobiology (Reading, England)2023

A single shell protein plays a major role in choline transport across the shell of the choline utilization microcompartment of

Jessica M Ochoa, Philip Dershwitz, Mary Schappert, Sharmistha Sinha, Taylor I Herring, Todd O Yeates, Thomas A Bobik

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica M OchoaUCLA-Molecular Biology Institute, University of California, Los Angeles, USA.
Philip DershwitzRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.
Mary SchappertRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.
Sharmistha SinhaRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.
Taylor I HerringRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.
Todd O YeatesUCLA-Molecular Biology Institute, University of California, Los Angeles, USA.
Thomas A BobikRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.

Funding

Dissecting the structure, function, and mechanisms of diverse protein-based metabolic organelles in bacteriaR01AI081146 · NIAID · IOWA STATE UNIVERSITY · PI BOBIK, THOMAS AQUINAS, YEATES, TODD O · 2009 to 2022
$6.5M
NIAID NIH HHS R01 AI081146
6 · The paper itself

Abstract

Bacterial microcompartments (MCPs) are widespread protein-based organelles that play important roles in the global carbon cycle and in the physiology of diverse bacteria, including a number of pathogens. MCPs consist of metabolic enzymes encapsulated within a protein shell. The main roles of MCPs are to concentrate enzymes together with their substrates (to increase reaction rates) and to sequester harmful metabolic intermediates. Prior studies indicate that MCPs have a selectively permeable protein shell, but the mechanisms that allow selective transport across the shell are not fully understood. Here we examine transport across the shell of the choline utilization (Cut) MCP of

Indexed as

Bacterial ProteinsCholineAmino Acid SequenceBacteriaEscherichia coliOrganellesBacterial ProteinsCholinecholineE. coli 536microcompartment

Identifiers

PMID37971493
PMCPMC10710832

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.