ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2024
Intravoxel incoherent motion (IVIM) detects femoral head ischemia in a piglet model of Legg-Calvé-Perthes disease.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Avascular necrosis of the femoral head following hysteroscopic myomectomy: Evaluation of bone perfusion using dynamic contrast-enhanced MRI and intravoxel incoherent motion.Skeletal radiology · 2026Article
- Relaxation Time Mapping of Early-Stage Osteonecrosis of the Femoral Head: An In Vivo Piglet Model Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Optimized analytical segmented method for improved intravoxel incoherent motion parameter extraction in low-perfused tissues.Magnetic resonance in medicine · 2025Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
There is a clinical need for alternatives to gadolinium contrast-enhanced magnetic resonance imaging (MRI) to facilitate early detection and assessment of femoral head ischemia in pediatric patients with Legg-Calvé-Perthes disease (LCPD), a juvenile form of idiopathic osteonecrosis of the femoral head. The purpose of this study was to determine if intravoxel incoherent motion (IVIM), a noncontrast-enhanced MRI method to simultaneously measure tissue perfusion and diffusion, can detect femoral head ischemia using a piglet model of LCPD. Twelve 6-week-old piglets underwent unilateral hip surgery to induce complete femoral head ischemia. The unoperated, contralateral femoral head served as a perfused control. The bilateral hips of the piglets were imaged in vivo at 3T MRI using IVIM and contrast-enhanced MRI 1 week after surgery. Median apparent diffusion coefficient (ADC) and IVIM parameters (diffusion coefficient: D
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