Evidence map›Paper›PMID 37971241›Full record

ArticleAntimicrobial agents and chemotherapy2023

Unraveling the mechanism of ceftaroline-induced allosteric regulation in penicillin-binding protein 2a: insights for novel antibiotic development against methicillin-resistant

Fangfang Jiao, Yiqiong Bao, Mengrong Li, Yan Zhang, Feng Zhang, Pinkai Wang, Jun Tao, Henry H Y Tong, Jingjing Guo

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Staphylococcal Cassette ChromosomeAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Uvarinol and Dichamanetin Derived fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fangfang JiaoCentre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.ORCID 0009-0001-1190-6938
Yiqiong BaoCollege of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Mengrong LiCollege of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Yan ZhangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Feng ZhangCollege of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Pinkai WangDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jun TaoDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Henry H Y TongCentre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Jingjing GuoCentre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.ORCID 0000-0002-4632-4364
Macao Polytechnic University · MONanjing Agricultural University · CNNanchang University · CN

Funding

Guizhou Provincial Basic Research Program QKHF-ZK(2021)G539Macao Polytechnic University RP/CAI-01/2022
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusAllosteric RegulationBacterial ProteinsMicrobial Sensitivity TestsPenicillin-Binding ProteinsAnti-Bacterial AgentsBacterial ProteinsPenicillin-Binding Proteinsallosteric regulationceftarolinemolecular dynamics simulationMRSApenicillin-binding protein 2aβ-lactams

Identifiers

PMID37971241
PMCPMC10720500
OpenAlexW4388734257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.