ArticleDevelopment (Cambridge, England)2023
Two modes of gene regulation by TFL1 mediate its dual function in flowering time and shoot determinacy of Arabidopsis.
Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- Time-dependent bistability leads to critical slowing down during floral transition in Arabidopsis.Nature communications · 2026Article
- Characterization of TERMINAL FLOWER 1 homologs from Macroptilium (Benth.) Urb.Plant reproduction · 2026Article
- RCN1 helps to alleviate the damage of drought stress to rice young spike differentiation.BMC plant biology · 2026Article
- An integrated fine-mapping, re-sequencing and transcriptome analysis provides further insights and candidate genes for silique number in oilseed rape (Brassica napus L.).BMC plant biology · 2026Article
- Contemporary hybridization among Arabis floodplain species creates opportunities for adaptation.The New phytologist · 2026Article
- Integrating meristem initiation and floral fate control: towardFrontiers in plant science · 2026Review
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- Seasons and shape: inflorescences from autumn to summer.Journal of experimental botany · 2025Review
- The MIR157-SPL15 module regulates flowering and inflorescence development in Arabidopsis thaliana under short days and in Arabis alpina.PLoS genetics · 2025Article
- Dancing molecules: group A bZIPs and PEBPs at the heart of plant development and stress responses.Journal of experimental botany · 2025Review
- FD and FDP bZIP transcription factors and FT florigen regulate floral development and control homeotic gene expression in Arabidopsis floral meristems.Development (Cambridge, England) · 2025Article
- Constitutive expression ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Identification of novel candidate genes for regulating oil composition in soybean seeds under environmental stresses.Frontiers in plant science · 2025Article
- A single nucleotide substitution introducing premature stop codon within CsTFL1 explains the determinate-2 phenotype in cucumber (Cucumis sativus L.).Scientific reports · 2024Article
- Article
- Prediction of plant complex traits via integration of multi-omics data.Nature communications · 2024Article
- A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.Development (Cambridge, England) · 2024Article
- Two modes of gene regulation by TFL1 mediate its dual function in flowering time and shoot determinacy of Arabidopsis.Development (Cambridge, England) · 2023Article
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13 authors at 2 institutions in 2 countries.
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Abstract
Plant organ primordia develop successively at the shoot apical meristem (SAM). In Arabidopsis, primordia formed early in development differentiate into vegetative leaves, whereas those formed later generate inflorescence branches and flowers. TERMINAL FLOWER 1 (TFL1), a negative regulator of transcription, acts in the SAM to delay flowering and to maintain inflorescence meristem indeterminacy. We used confocal microscopy, time-resolved transcript profiling and reverse genetics to elucidate this dual role of TFL1. We found that TFL1 accumulates dynamically in the SAM reflecting its dual function. Moreover, TFL1 represses two major sets of genes. One set includes genes that promote flowering, expression of which increases earlier in tfl1 mutants. The other set is spatially misexpressed in tfl1 inflorescence meristems. The misexpression of these two gene sets in tfl1 mutants depends upon FD transcription factor, with which TFL1 interacts. Furthermore, the MADS-box gene SEPALLATA 4, which is upregulated in tfl1, contributes both to the floral transition and shoot determinacy defects of tfl1 mutants. Thus, we delineate the dual function of TFL1 in shoot development in terms of its dynamic spatial distribution and different modes of gene repression.
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