Evidence map›Paper›PMID 37970923›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2023

Oncogenic transmembrane protein 158 drives the PI3K/Akt signaling pathway to accelerate gastric cancer cell growth.

Xiaoting Cui, Jie Lu, Cuijuan Zhao, Yu Duan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiaoting CuiDepartment of Gastroenterology, The Third Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Baogang Hospital, Baotou, China.ORCID http://orcid.org/0009-0004-1497-5076
Jie LuDepartment of Gastroenterology, The Fourth Affiliated Hospital of Baotou Medical College, Baotou Eighth Hospital, Baotou, China.ORCID http://orcid.org/0009-0006-4152-9834
Cuijuan ZhaoDepartment of Gastroenterology, The Third Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Baogang Hospital, Baotou, China.ORCID http://orcid.org/0009-0004-8963-6896
Yu DuanDepartment of Gastroenterology, The Third Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Baogang Hospital, Baotou, China.ORCID http://orcid.org/0009-0006-0067-1631
Third Affiliated Hospital of Inner Mongolia Medical College · CNBaotou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is a serious threat to human health and an important cause of cancer-related death. Herein, we evaluated the influence of transmembrane protein 158 (TMEM158) on GC cell growth. According to Genomic Spatial Event (GSE) and The Cancer Genome Atlas (TCGA) databases, TMEM158 content is amplified in GC tissues. The diagnostic value of TMEM158 expression in GC is huge. GC sufferers with high expression of TMEM158 were associated with poor overall survival. In addition, TMEM158 content was increased in GC cells. TMEM158 promoted GC cell proliferation by modulating the PI3K/Akt signaling pathway. Lack of TMEM158 reduced GC tumor growth. Collectively, TMEM158 accelerated GC cell proliferation by modulating the PI3K/Akt signaling pathway, making it a prospective biomarker for survival in GC patients.

Indexed as

Proto-Oncogene Proteins c-aktStomach NeoplasmsCell Line, TumorCell ProliferationCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHumansMembrane ProteinsPhosphatidylinositol 3-KinasesSignal TransductionTumor Suppressor ProteinsMembrane ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTMEM158 protein, humanTumor Suppressor Proteins

Identifiers

PMID37970923
PMCPMC10644964
OpenAlexW4388641600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.