ReviewDeutsches Arzteblatt international2024
Fracture-Related Infection-Epidemiology, Etiology, Diagnosis, Prevention, and Treatment.
Review in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027Review
- Translation-driven design: development of an antibiotic-loaded hydrogel for the management of orthopaedic device-related infection.Bioactive materials · 2026Article
- Insertion sequence elements associated with Staphylococcus epidermidis evolution in persistent orthopaedic device-related infections.BMC genomics · 2026Article
- Impact of Infection Timing on Outcomes: A Comparative Study of Periprosthetic Joint and Fracture-Related Infections.Orthopaedic surgery · 2026Article
- Article
- Septic arthritis following intra-articular corticosteroid injections: a retrospective analysis.Archives of orthopaedic and trauma surgery · 2026Article
- Is Perioperative Antibiotic Prophylaxis Necessary for Pediatric and Adolescent ESIN Osteosyntheses?-A Retrospective Analysis of 939 Surgical Procedures.Children (Basel, Switzerland) · 2026Article
- Twenty common errors in the prevention, diagnosis, and treatment of fracture-related infection (FRI).Journal of bone and joint infection · 2026Review
- Predictive value of a preoperative computed tomography-derived perifracture soft-tissue envelope index for fracture-related infection after open reduction and internal fixation of tibial plateau fractures.Frontiers in medicine · 2026Article
- Sonication versus peri-implant tissue culture in fracture-related infection: diagnostic performance and therapeutic consequences in a single-center cohort.Journal of bone and joint infection · 2026Article
- [Resection of the second ray applying the palmar approach].Operative Orthopadie und Traumatologie · 2025Review
- Life after bone infection: a retrospective comparison of quality of life in patients with periprosthetic joint infection and fracture-related infections.Journal of orthopaedic surgery and research · 2025Article
- [Bacteriophages for the treatment of musculoskeletal infections-An overview of clinical use, open questions, and legal framework].Orthopadie (Heidelberg, Germany) · 2025Article
- Integrating Super-Oxidised Solutions into Multimodal Strategies for Orthopaedic Infection Prevention and Management.Cureus · 2025Review
- Combined effects of low temperature, hyperosmolarity and seawater-conditioned pathogens on open fracture healing in a rat model simulating circumpolar environments.Journal of orthopaedic surgery and research · 2025Article
- Orthopedic implant-related ESBLJournal of surgical case reports · 2025Article
- In vitro experimental study of MC-PMMA containing vancomycin for the prevention of infection in open bone defects.Journal of materials science. Materials in medicine · 2025Article
- Enhancing bone regeneration using kaempferol as an osteoprotective compound: signaling mechanisms, delivery strategies, and potential applications.Journal of biological engineering · 2025Review
- Clinical and functional outcomes of masquelet technique for treating Fracture-related Infections(FRIs) in shoulder girdle.Scientific reports · 2025Article
- Association between periodontitis and fracture-related infection in patients with severe open fractures of the upper and/or lower extremities.BMC oral health · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFracture-related infection (FRI) is a challenge to physicians and other workers in health care. In 2018, there were 7253 listed cases of FRI in Germany, corresponding to an incidence of 10.7 cases per 100 000 persons per year.
methodsThis review is based on pertinent publications retrieved from a search in PubMed with the search terms "fracture," "infection," "guideline," and "consensus." Aside from the primary literature, international guidelines and consensus recommendations were evaluated as well.
resultsFRI arise mainly from bacterial contamination of the fracture site. Staphylococcus aureus is the most commonly detected pathogen. The treatment is based on surgery and antibiotics and should be agreed upon by an interdisciplinary team; it is often difficult because of biofilm formation. Treatment options include implant-preserving procedures and single-stage, two-stage, or multi-stage implant replacement. Treatment failure occurs in 10.3% to 21.4% of cases. The available evidence on the efficacy of various treatment approaches is derived mainly from retrospective cohort studies (level III evidence). Therefore, periprosthetic joint infections and FRI are often discussed together.
conclusionFRI presents an increasing challenge. Preventive measures should be optimized, and the treatment should always be decided upon by an interdisciplinary team. Only low-level evidence is available to date to guide diagnostic and treatment decisions. High-quality studies are therefore needed to help us meet this challenge more effectively.
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