Evidence map›Paper›PMID 37970542›Full record

ArticlebioRxiv : the preprint server for biology2023

Parietal stimulation reverses age-related decline in exploration, learning, and decision-making.

Eun Jung Hwang, Sayli Korde, Ying Han, Jaydeep Sambangi, Bowen Lian, Ama Owusu-Ofori, Megi Diasamidze, Lea M Wong, Nadine Pickering, Sam Begin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eun Jung HwangCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.ORCID 0000-0003-2786-5963
Sayli KordeCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Ying HanCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Jaydeep SambangiChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Bowen LianChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Ama Owusu-OforiCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Megi DiasamidzeCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Lea M WongCell Biology and Anatomy, Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Nadine PickeringChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
Sam BeginChicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.

Funding

Neural circuits for decision makingR56MH130488 · NIMH · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI HWANG, EUN JUNG · 2023 to 2024
$780k
NIMH NIH HHS R56 MH130488
6 · The paper itself

Abstract

Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-driven learning could be a key to countering cognitive aging.

Identifiers

PMID37970542
PMCPMC10642975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.