ArticleWorld journal of gastroenterology2023
Expression characteristics of peripheral lymphocyte programmed death 1 and FoxP3
Article in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Mechanisms and therapeutic strategies to reveal and overcome T-cell dysfunction in gastric cancer: translation from basic research to clinical application.Frontiers in immunology · 2025Review
- Dysregulation of systemic immunity and its clinical application in gastric cancer.Frontiers in immunology · 2024Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundProgrammed death 1 (PD-1) and CD4
aimTo observe and analyze the expression characteristics of peripheral lymphocyte PD-1 and FoxP3
methodsTwenty-nine stomach cancer patients undergoing chemotherapy after a D2 gastrectomy provided 10 mL peripheral blood samples at each phase of the perioperative period and during chemotherapy. This study also included 29 age-matched healthy donors as a control group. PD-1 expression was detected on lymphocytes, including CD4
resultsWe observed a significant increase of PD-1 expression on immune subsets and a larger number of FoxP3
conclusionThe observed alterations in PD-1 expression and the activation of regulatory T cells during gastric cancer treatment may offer novel insights for future investigations into tumor immune evasion and the clinical application of anti-PD-1 antibodies in gastric cancer.
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