Evidence map›Paper›PMID 37969731›Full record

ArticleActa pharmaceutica Sinica. B2023

Engineering cannabidiol synergistic carbon monoxide nanocomplexes to enhance cancer therapy

Chang Xiao, Yue Sun, Jialong Fan, William Nguyen, Simin Chen, Ying Long, Wei Chen, Aiguo Zhu, Bin Liu

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Chang XiaoCollege of Biology, Hunan University, Changsha 410082, China.
Yue SunCollege of Biology, Hunan University, Changsha 410082, China.
Jialong FanCollege of Biology, Hunan University, Changsha 410082, China.
William NguyenDepartment of Physics, the University of Texas at Arlington, Arlington, TX 76019, USA.
Simin ChenCollege of Biology, Hunan University, Changsha 410082, China.
Ying LongCollege of Biology, Hunan University, Changsha 410082, China.
Wei ChenDepartment of Physics, the University of Texas at Arlington, Arlington, TX 76019, USA.
Aiguo ZhuInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China.
Bin LiuCollege of Biology, Hunan University, Changsha 410082, China.
Hunan University · CNThe University of Texas at Arlington · USInstitute of Bast Fiber Crops · CNNingxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although carbon monoxide (CO)-based treatments have demonstrated the high cancer efficacy by promoting mitochondrial damage and core-region penetrating ability, the efficiency was often compromised by protective autophagy (mitophagy). Herein, cannabidiol (CBD) is integrated into biomimetic carbon monoxide nanocomplexes (HMPOC@M) to address this issue by inducing excessive autophagy. The biomimetic membrane not only prevents premature drugs leakage, but also prolongs blood circulation for tumor enrichment. After entering the acidic tumor microenvironment, carbon monoxide (CO) donors are stimulated by hydrogen oxide (H

Indexed as

Autolysosome degradationAutophagic fluxCannabidiolCarbon monoxide therapyExcessive autophagyMetastasesReactive oxygen speciesTriple-negative breast cancer

Identifiers

PMID37969731
PMCPMC10638503
OpenAlexW4378713755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.