ArticleWorld journal of gastrointestinal surgery2023
Effect of low anterior resection syndrome on quality of life in colorectal cancer patients: A retrospective observational study.
Article in World journal of gastrointestinal surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- The Clinical Relevance of the Rectosigmoid Brake in Surgical Disorders and Therapies: A Systematic Review of Colonic Manometry Studies.Neurogastroenterology and motility · 2026Pooled it
- Narrative therapy and resilience training improve recovery and survival after intersphincteric resection for low rectal cancer: a randomized trial.The oncologist · 2025Trial
- Living with low anterior resection syndrome after rectal cancer surgery: challenges, self-management, and supportive care priorities.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Structured pelvic floor physiotherapy rehabilitation for low anterior resection syndrome in colorectal cancer: An Australian feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Stigma, stoma acceptance, quality of life among patients with colorectal cancer intestinal ostomy: a cross-sectional study.Frontiers in oncology · 2026Article
- Perceived stress profiles, resourcefulness, and quality of life among patients with colorectal cancer and intestinal ostomy: a cross-sectional latent profile and mediation study.Frontiers in psychiatry · 2026Article
- Case Report: Quantitative and qualitative evaluation for electroacupuncture combined with moxibustion in the treatment of recalcitrant low anterior resection syndrome.Frontiers in medicine · 2026Article
- Impact of low anterior resection syndrome after rectal surgery on sleep quality.Surgery today · 2025Article
- Score assessment and treatment in patients presenting with low anterior resection syndrome after sphincter-sparing rectal cancer surgery.International journal of colorectal disease · 2025Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow anterior resection syndrome (LARS) is a common complication of anus-preserving surgery in patients with colorectal cancer, which significantly affects patients' quality of life.
aimTo determine the relationship between the incidence of LARS and patient quality of life after colorectal cancer surgery and to establish a LARS prediction model to allow perioperative precision nursing.
methodsWe reviewed the data from patients who underwent elective radical resection for colorectal cancer at our institution from April 2013 to June 2020 and completed the LARS score questionnaire and the European Organization for Research and Treatment of Cancer Core Quality of Life and Colorectal Cancer Module questionnaires. According to the LARS score results, the patients were divided into no LARS, mild LARS, and severe LARS groups. The incidence of LARS and the effects of this condition on patient quality of life were determined. Univariate and multivariate analyses were performed to identify independent risk factors for the occurrence of LARS. Based on these factors, we established a risk prediction model for LARS and evaluated its performance.
resultsAmong the 223 patients included, 51 did not develop LARS and 171 had mild or severe LARS. The following quality of life indicators showed significant differences between patients without LARS and those with mild or severe LARS: Physical, role, emotional, and cognitive function, total health status, fatigue, pain, shortness of breath, insomnia, constipation, and diarrhea. Tumor size, partial/total mesorectal excision, colostomy, preoperative radiotherapy, and neoadjuvant chemotherapy were identified to be independent risk factors for LARS. A LARS prediction model was successfully established, which demonstrated an accuracy of 0.808 for predicting the occurrence of LARS.
conclusionThe quality of life of patients with LARS after colorectal cancer surgery is significantly reduced.
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