Evidence map›Paper›PMID 37969581›Full record

ArticleChemical science2023

Parallel kinetic resolution of aziridines

Juan Liu, Yi-Ying Du, Yu-Shi He, Yan Liang, Shang-Zhong Liu, Yi-Yi Li, Yi-Ming Cao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Juan LiuCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Yi-Ying DuCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Yu-Shi HeCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Yan LiangCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Shang-Zhong LiuCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Yi-Yi LiCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.
Yi-Ming CaoCollege of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University Beijing 100193 China caoym@cau.edu.cn.ORCID https://orcid.org/0000-0001-9929-8561
State Forestry and Grassland Administration · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a chiral phosphoric acid catalyzed apparent hydrolytic ring-opening reaction of racemic aziridines in a regiodivergent parallel kinetic resolution manner. Harnessing the acyloxy-assisted strategy, the highly stereocontrolled nucleophilic ring-opening of aziridines with water is achieved. Different kinds of aziridines are applicable in the process, giving a variety of enantioenriched aromatic or aliphatic amino alcohols with up to 99% yields and up to >99.5 : 0.5 enantiomeric ratio. Preliminary mechanistic study as well as product elaborations were inducted as well.

Identifiers

PMID37969581
PMCPMC10631200
OpenAlexW4387587313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.