Evidence map›Paper›PMID 37969491›Full record

ArticleJSES international2023

The effect of augmenting suture material with magnesium and platelet-rich plasma on the

Lukas N Muench, Lisa Tamburini, Danielle Kriscenski, Daniel P Berthold, Marco-Christopher Rupp, Mark P Cote, Mary Beth McCarthy, Augustus D Mazzocca

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JSES international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lukas N MuenchDepartment of Sports Orthopaedics, Technical University of Munich, Munich, Germany.
Lisa TamburiniDepartment of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USA.
Danielle KriscenskiDepartment of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USA.
Daniel P BertholdDepartment of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU, Munich, Germany.
Marco-Christopher RuppDepartment of Sports Orthopaedics, Technical University of Munich, Munich, Germany.
Mark P CoteDepartment of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USA.
Mary Beth McCarthyDepartment of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USA.
Augustus D MazzoccaMassachusetts General Hospital, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA.
University of Connecticut · USTechnical University of Munich · DELudwig-Maximilians-Universität München · DEMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Connective tissue subacromial bursa-derived progenitor cells (SBDCs) have been suggested as a potent biologic augment to promote healing of the repaired rotator cuff tendon. Maximizing the amount of retained progenitor cells at the tendon repair site is essential for ensuring an optimal healing environment, warranting a search for proadhesive and proliferative adjuvants. The purpose was to evaluate the effect of magnesium (Mg), platelet-rich plasma (PRP), and a combination of both adjuvants on the Methods: SBDCs were isolated from subacromial bursa samples harvested during rotator cuff repair and cultured in growth media. Commercially available collagen-coated nonabsorbable flat-braided suture was cut into 1-inch pieces, placed into 48-well culture dishes, and sterilized under ultraviolet light. Either a one-time dose of 5 mM sterile Mg, 0.2 mL of PRP, or a combination of both adjuvants was added, while a group without treatment served as a negative control. Cellular proliferation and adhesion assays on suture material were performed for each treatment condition. Results: Augmenting the suture with Mg resulted in a significantly increased cellular adhesion (total number of attached cells) of SBDCs compared to PRP alone (31,527 ± 19,884 vs. 13,619 ± 8808; Conclusion: Augmenting suture material with Mg resulted in a significantly increased cellular adhesion of SBDCs compared to untreated suture material, as well as augmentation with PRP alone or a combination of both adjuvants. Further, Mg with or without PRP augmentation achieved a significant increase in the cellular proliferation of SBDCs on suture material compared to untreated sutures and augmentation with PRP alone. Application of Mg may be a clinically feasible approach to optimizing the use of SBDCs as a biological augment in rotator cuff repair, while combined augmentation with PRP may harness the full potential for optimized tissue recovery due to the high concentration of PRP-derived growth factors.

Indexed as

Biologic augmentationCellular adhesionMagnesiumPlatelet-rich plasmaProgenitor cellsProliferationSubacromial bursaSuture material

Identifiers

PMID37969491
PMCPMC10638578
OpenAlexW4385286932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.