Evidence map›Paper›PMID 37969048›Full record

ArticleBrain and behavior2023

Association between the blood pressure variability and cognitive decline in Parkinson's disease.

Yi Xiao, Tianmi Yang, Lingyu Zhang, Qianqian Wei, Ruwei Ou, Yanbing Hou, Kuncheng Liu, Junyu Lin, Qirui Jiang, Huifang Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. A reset on our reclined position-a call to prioritize neurogenic supine hypertension in the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi XiaoDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Tianmi YangDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Lingyu ZhangHealth Management Center, West China Hospital of Sichuan University, Chengdu, China.
Qianqian WeiDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Ruwei OuDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yanbing HouDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Kuncheng LiuDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Junyu LinDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Qirui JiangDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Huifang ShangDepartment of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-0947-1151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHigh visit-to-visit blood pressure variability (BPV) was found to be associated with cognitive decline in the elderly. This study aimed to investigate the impact of visit-to-visit BPV on cognition in patients with early-stage Parkinson's disease (PD).

designThis is a retrospective analysis of a prospective cohort. SETTING AND

participantsA total of 297 patients with early-stage PD (103 mild cognitive impairments [PD-MCI] and 194 normal cognitions [PD-NC] at baseline) were included from the Parkinson's Progression Markers Initiative study.

methodsVariation independent of mean (VIM) of the first year was used as the indicator of BPV. The Montreal Cognitive Assessment (MoCA) was used to assess global cognition. Patients were divided into PD-MCI and PD-NC according to the MoCA score at baseline. Longitudinal cerebrospinal fluid (Aβ-42, Aβ, α-synuclein, neurofilament light protein, tau phosphorylated at the threonine 181 position, total tau, glial fibrillary acidic protein) and serum (neurofilament light protein) biomarkers were assessed. The Bayesian linear growth model was used to evaluate the relationship between baseline BPV and the rate of change in cognition and biomarkers.

resultsHigher systolic VIM of the first year was related to a greater rate of decline in MoCA score in the following years in PD-MCI (β = -.15 [95% CI -.29, -.01]). No association was found between BPV and biomarkers. CONCLUSION AND IMPLICATIONS: Higher systolic VIM predicted a steeper decline in cognitive tests in PD-MCI independently from the mean value of blood pressure, orthostatic hypotension, and supine hypertension.

Indexed as

Cognitive DysfunctionParkinson DiseaseAgedAmyloid beta-PeptidesBayes TheoremBiomarkersBlood PressureHumansNeurofilament ProteinsProspective StudiesRetrospective StudiesTumor Necrosis Factor Ligand Superfamily Member 14Amyloid beta-PeptidesBiomarkersNeurofilament ProteinsTumor Necrosis Factor Ligand Superfamily Member 14ambulatory blood pressure monitoringbiomarkercognitionParkinson's disease

Identifiers

PMID37969048
PMCPMC10726805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.