Evidence map›Paper›PMID 37968805›Full record

ArticleJournal of dental research2024

Sex-Related Effect of Aging in Gingival Gamma-Delta T Cells.

V Tubero Euzebio Alves, M E C Bruno, S Mukherjee, L Wang, R J Danaher, L Su, M E Starr, O A Gonzalez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

V Tubero Euzebio AlvesCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
M E C BrunoDepartment of Surgery, College of Medicine, University of Kentucky, Lexington, KY, USA.
S MukherjeeDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA.
L WangCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
R J DanaherCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
L SuDepartment of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA.
M E StarrDepartment of Surgery, College of Medicine, University of Kentucky, Lexington, KY, USA.
O A GonzalezCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
University of Kentucky · US

Funding

OHPP Oral Health Pilot Program P30GM110788 · NIGMS · UNIVERSITY OF KENTUCKY · PI KYRKANIDES, STEPHANOS · 2014 to 2018
$5.4M
Visceral fat gamma delta T cells in sepsis pathogenesisR01GM129532 · NIGMS · UNIVERSITY OF KENTUCKY · PI STARR, MARLENE ELENA · 2018 to 2022
$1.6M
The Role of Gamma Delta (γδ)-T Cells in Age-Associated Adipose Tissue InflammationR56AG061508 · NIA · UNIVERSITY OF KENTUCKY · PI STARR, MARLENE ELENA · 2019 to 2019
$377k
NIA NIH HHS R56 AG061508NIGMS NIH HHS P30 GM110788NIGMS NIH HHS R01 GM129532
6 · The paper itself

Abstract

Aging affects the number and function of gamma-delta (γδ) T cells in a tissue-specific manner, modifying the risk for inflammatory disease. These aging-related γδT-cell variations in gingival tissues that could increase the risk for inflammation and periodontal disease remain unknown. Here we sought to identify quantitative and qualitative variations in gingival γδT cells associated with aging that could have an impact in oral immunoinflammatory responses. For this, gingival tissues from young (4 mo) and aged (24 mo) male and female mice were collected and analyzed by flow cytometry. Cell suspensions were stimulated and stained with eFluor450 (cell viability), anti-CD45 (hematopoietic cells), anti-CD3 (lymphocytes), anti-TCRγδ (γδT cells), anti-IL-15rα (cell proliferation), and anti-Notch-3 (senescence marker). Detection of intracellular cytokines IL-17A and interferon γ (IFNγ) was performed. Gingival expression of specific γ- and δ-chains and cytokines was evaluated by quantitative reverse transcription polymerase chain reaction. A significantly higher number of IL-17A-producing γδT cells and IL-17A expression levels were observed in gingival tissues from aged females but not males. Similarly, the number of gingival Notch-3

Indexed as

Interleukin-17Receptors, Antigen, T-Cell, gamma-deltaAgingAnimalsCytokinesFemaleFlow CytometryInterferon-gammaMaleMiceTh17 CellsCytokinesInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, gamma-deltagingival conventional T cellsIFNγIL-15RIL-17ANotch-3sexual dimorphism

Identifiers

PMID37968805
PMCPMC10985387
OpenAlexW4388733048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.