Evidence map›Paper›PMID 37968649›Full record

SynthesisVirology journal2023

Immune escape of SARS-CoV-2 variants to therapeutic monoclonal antibodies: a system review and meta-analysis.

Huichun Shi, Jiajia Sun, Yigang Zeng, Xiaomeng Wang, Shanshan Liu, Lijun Zhang, Enming Shao

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huichun Shi *Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jiajia Sun *The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450099, China.
Yigang ZengShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Xiaomeng WangShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Shanshan LiuShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Lijun ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. zhanglijun1221@163.com.
Enming ShaoShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. shaoenming@shphc.org.cn.

Funding

National Natural Science Funds 81271834National Science and Technology Program 2017ZX09304027Shanghai Clinical Research Center for Infectious Disease (HIV/AIDS) 20MC1920100Shanghai Municipal Health Commission Scientific Research Project 20194Y0088
6 · The paper itself

Abstract

backgroundOmicron's high transmissibility and variability present new difficulties for COVID-19 vaccination prevention and therapy. In this article, we analyzed the sensitivity of vaccine-induced antibodies as well as the effect of booster vaccinations against Omicron sublineages.

methodsWe looked for Randomized Controlled Trials and cohort studies that reported the COVID-19 vaccines against Omicron sublineages up to 28 July 2022 through PubMed, the Cochrane Library, EMBASE, and Web of Science. Quantitative synthesis was carried out using Stata 16.0 and RevMa5.3, then the serum NT50 and antibody sensitivity to neutralize Omicron sublineages were assessed before and after booster vaccination. This study was registered with PROSPERO number CRD42022350477.

resultsThis meta-analysis included 2138 patients from 20 studies, and the booster vaccination against Omicron sublineages showed a significant difference compared to 2 dosage: BA.1/BA.1.1 (SMD = 0.80, 95% CI: 0.75-0.85, P = 0.00), BA.2/BA.2.12.1 (SMD = 0.77, 95% CI: 0.69-0.85, P = 0.00), BA.3 (SMD = 0.91, 95% CI: 0.83-1.0, P = 0.00), and BA.4/5 (SMD = 0.77, 95% CI: 0.60-0.94, P = 0.00). The sensitivity of vaccines-induced antibodies decreased by at least 5-folds after booster vaccination, particularly in the case of BA.4/5 which had the most notable decline in vaccine effectiveness.

conclusionAfter the booster vaccination, the NT50 and the neutralization ability of vaccine-induced antibodies increased, but the susceptibility of antibodies decreased compared with the control virus, which may be a clue for future Omicron sublineages prevention.

Indexed as

Antibodies, MonoclonalCOVID-19Antibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesHumansSARS-CoV-2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesNeutralizationSARS-CoV-2 OmicronVaccines-induced antibodies

Identifiers

PMID37968649
PMCPMC10652597

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.