ArticleBMC ophthalmology2023
Corneal biomechanics in normal and subclinical keratoconus eyes.
Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Toll-like receptors in corneal ectasia: linking innate immunity to keratoconus.Molecular biology reports · 2026Pooled it
- Obesity and Keratoconus: A Mediation Study Based on the Chinese Keratoconus Cohort.Translational vision science & technology · 2026Article
- Article
- Proteomic Analysis of Human Corneal Keratocytes Reveals Mechanical Strain-Dependent Changes in Cellular Function.Investigative ophthalmology & visual science · 2026Article
- Artificial Intelligence-Derived Biomechanical Index for Early Corneal Ectasia Detection: Advancing Beyond Tomography.Ophthalmology science · 2026Article
- Enhancing the diagnostic precision of subclinical keratoconus by combining indices from Scheimpflug tomography, corneal biomechanics, and anterior segment optical coherence tomography.International journal of ophthalmology · 2026Article
- Intraocular pressure measurement in keratoconus: a narrative review.International journal of ophthalmology · 2026Review
- Corneal Biomechanics Before and After Descemet Membrane Endothelial Keratoplasty in Patients with Fuchs Endothelial Corneal Dystrophy.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The Effects of Eye Rubbing on Corneal Topography and Biomechanics in Children With Allergic Conjunctivitis.Translational vision science & technology · 2025Observational
- Analysis of pulsatile motion in the murine cornea using phase-sensitive visible-light optical coherence tomography.Biomedical optics express · 2025Article
- Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies.Eye and vision (London, England) · 2025Review
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management.Journal of ophthalmology · 2025Review
- Diagnostic value of corneal optical densitometry in keratoconus.International ophthalmology · 2024Article
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus.Journal of ophthalmology · 2024Article
- Brillouin microscopy for focal biomechanical measurements in normal and keratoconic corneas: A narrative review.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe diagnosis of keratoconus, as the most prevalent corneal ectatic disorder, at the subclinical stage gained great attention due to the increased acceptance of refractive surgeries. This study aimed to assess the pattern of the corneal biomechanical properties derived from Corneal Visualization Scheimpflug Technology (Corvis ST) and evaluate the diagnostic value of these parameters in distinguishing subclinical keratoconus (SKC) from normal eyes.
methodsThis prospective study was conducted on 73 SKC and 69 normal eyes. Subclinical keratoconus eyes were defined as corneas with no clinical evidence of keratoconus and suspicious topographic and tomographic features. Following a complete ophthalmic examination, topographic and tomographic corneal assessment via Pentacam HR, and corneal biomechanical evaluation utilizing Corvis ST were done.
resultsSubclinical keratoconus eyes presented significantly higher Deformation Amplitude (DA) ratio, Tomographic Biomechanical Index (TBI), and Corvis Biomechanical Index (CBI) rates than the control group. Conversely, Ambrósio Relational Thickness to the Horizontal profile (ARTh), and Stiffness Parameter at the first Applanation (SPA1) showed significantly lower rates in SKC eyes. In diagnosing SKC from normal eyes, TBI (AUC: 0.858, Cut-off value: > 0.33, Youden index: 0.55), ARTh (AUC: 0.813, Cut-off value: ≤ 488.1, Youden index: 0.58), and CBI (AUC: 0.804, Cut-off value: > 0.47, Youden index: 0.49) appeared as good indicators.
conclusionsTBI, CBI, and ARTh parameters could be valuable in distinguishing SKC eyes from normal ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.