Evidence map›Paper›PMID 37968443›Full record

ArticleScientific reports2023

Exploring the immunogenicity of an insect-specific virus vectored Zika vaccine candidate.

Manette Tanelus, Krisangel López, Shaan Smith, John A Muller, Danielle L Porier, Dawn I Auguste, William B Stone, Sally L Paulson, Albert J Auguste

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Zika virus: an overview update.Current opinion in HIV and AIDS · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Manette TanelusDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Krisangel LópezDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Shaan SmithDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
John A MullerDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Danielle L PorierDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Dawn I AugusteDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
William B StoneDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Sally L PaulsonDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.
Albert J AugusteDepartment of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. jauguste@vt.edu.
Virginia Tech · US

Funding

A Novel Strategy for Generating Safe and Effective Flavivirus VaccinesR01AI153433 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI AUGUSTE, ALBERT J. · 2020 to 2024
$2.0M
Pre-clinical evaluation of alpha-Cache; a novel RNA vaccine for an emerging orthobunyavirusR21AI178550 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI AUGUSTE, ALBERT J., ERASMUS, JESSE HONG-SAE · 2023 to 2024
$469k
Howard Hughes Medical Institute Gilliam Fellowship for Advanced StudyNIAID NIH HHS R01 AI153433NIAID NIH HHS R21 AI178550NIH HHS R01AI153433
6 · The paper itself

Abstract

Zika virus (ZIKV) is an important re-emerging flavivirus that presents a significant threat to human health worldwide. Despite its importance, no vaccines are approved for use in humans. Insect-specific flaviviruses (ISFVs) have recently garnered attention as an antigen presentation platform for vaccine development and diagnostic applications. Here, we further explore the safety, immunogenicity, and efficacy of a chimeric ISFV-Zika vaccine candidate, designated Aripo-Zika (ARPV/ZIKV). Our results show a near-linear relationship between increased dose and immunogenicity, with 10

Indexed as

Viral VaccinesZika VirusZika Virus InfectionAnimalsAntibodies, NeutralizingAntibodies, ViralChlorocebus aethiopsHumansImmunogenicity, VaccineMiceAntibodies, NeutralizingAntibodies, ViralViral Vaccines

Identifiers

PMID37968443
PMCPMC10651913
OpenAlexW4388700813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.