Evidence map›Paper›PMID 37968427›Full record

ArticleJournal of applied genetics2024

Complex effects of the exo-xis region of the Shiga toxin-converting bacteriophage Φ24

Sylwia Bloch, Bożena Nejman-Faleńczyk, Katarzyna Licznerska, Aleksandra Dydecka, Gracja Topka-Bielecka, Agnieszka Necel, Alicja Węgrzyn, Grzegorz Węgrzyn

Open access · hybridAbstract read
In one paragraph

Article in Journal of applied genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sylwia BlochDepartment of Molecular Biology, Faculty of Biology, University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0002-3451-3619
Bożena Nejman-FaleńczykDepartment of Molecular Biology, Faculty of Biology, University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0003-4468-0733
Katarzyna LicznerskaDepartment of Physiology, Medical University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0003-4907-5401
Aleksandra DydeckaUniventum Labs Ltd., Gdansk, Poland.ORCID https://orcid.org/0000-0003-1248-3508
Gracja Topka-BieleckaUniventum Labs Ltd., Gdansk, Poland.ORCID https://orcid.org/0000-0003-4085-4900
Agnieszka NecelDepartment of Medical Microbiology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0002-9051-4077
Alicja WęgrzynPhage Therapy Center, University Center for Applied and Interdisciplinary Research, University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0002-3073-2814
Grzegorz WęgrzynDepartment of Molecular Biology, Faculty of Biology, University of Gdansk, Gdansk, Poland. grzegorz.wegrzyn@ug.edu.pl.ORCID http://orcid.org/0000-0003-4042-7466
University of Gdańsk · PLGdańsk Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lambdoid bacteriophages are excellent models in studies on molecular aspects of virus-host interactions. However, some of them carry genes encoding toxins which are responsible for virulence of pathogenic strains of bacteria. Shiga toxin-converting bacteriophages (Stx phages) encode Shiga toxins that cause virulence of enterohemorrhagic Escherichia coli (EHEC), and their effective production depends on Stx prophage induction. The exo-xis region of the lambdoid phage genome consists of genes which are dispensable for the phage multiplication under laboratory conditions; however, they might modulate the virus development. Nevertheless, their exact effects on the phage and host physiology remained unclear. Here, we present results of complex studies on the role of the exo-xis region of bacteriophage Φ24

Indexed as

Escherichia coliShiga ToxinBacteriophage lambdaLysogenyProteomicsShiga Toxinexo-xis regionGene expressionShiga toxin-producing E. coli (STEC)Stx phagesThe lysis vs. lysogenization decision

Identifiers

PMID37968427
PMCPMC10789677
OpenAlexW4388712872

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.