ArticleNature2023
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
20.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Therapeutic Modulation of Meningeal Lymphatics: A Systematic Review of Preclinical Evidence Across Neurological Disorders.Cellular and molecular neurobiology · 2025Pooled it
- Role of meningeal lymphatic vessels in brain homeostasis.Frontiers in immunology · 2025Pooled it
- Testing effects of paced breathing on plasma Aβ and brain perivascular spaces.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2026Trial
- Neuroinflammation and noradrenergic modulation with β2-adrenoceptors: Emerging therapeutic targets for Parkinson's diseases.Neural regeneration research · 2026Article
- Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuromonitoring in the Decompressed Brain: Rethinking Physiology, Monitoring, and Thresholds After Decompressive Craniectomy.Neurocritical care · 2026Article
- Ultrasound-Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High frame ratebioRxiv : the preprint server for biology · 2026Article
- The Glymphatic System in α-Synucleinopathies.Yonsei medical journal · 2026Review
- ACP5-positive macrophages contribute to cerebral oedema and neuroinflammation after traumatic brain injury.Clinical and translational medicine · 2026Article
- Brain clearance physiology in traumatic brain injury: From disruption to therapeutic potential.The Journal of physiology · 2026Article
- Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models.Nature biotechnology · 2026Article
- The glymphatic system in sleep: a nexus of waste clearance, brain homeostasis, and disease intervention.Molecular psychiatry · 2026Review
- Intrathecal infusion of hypertonic fluid enables CSF Flow Enhancement (CFE) to facilitate nanoparticle delivery to the brain and spinal cord.bioRxiv : the preprint server for biology · 2026Article
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- microGLYMPH: a conceptual translational roadmap for microdialysis‑based assessment of CSF-interstitial solute exchange in acquired brain injury.Critical care (London, England) · 2026Review
- Glymphatic dysfunction: a unifying hypothesis for delirium.Nature reviews. Neurology · 2026Review
- Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice.bioRxiv : the preprint server for biology · 2026Article
- Efficacy and Predictors of Success of External Ventricular Drainage for the Management of Traumatic Intracranial Hypertension: A Retrospective Multicenter Cohort Study.Neurocritical care · 2026Article
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Fluids and barriers of the CNS · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Rashad HussainCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA. rashad_hussain@urmc.rochester.edu.ORCID 0000-0003-2830-9678
Jeffrey TithofDepartment of Mechanical Engineering, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-2083-0901
Wei WangCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Arokoruba Cheetham-WestCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Wei SongCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Weiguo PengCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Björn SigurdssonCenter for Translational Neuromedicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.ORCID 0000-0002-7484-7779
Daehyun KimDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
Qian SunCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Sisi PengCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.
Virginia PláCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-5501-0789
Douglas H KelleyDepartment of Mechanical Engineering, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-9658-2954
Hajime HiraseCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-3806-6905
Jorge A Castorena-GonzalezDepartment of Pharmacology, School of Medicine, Tulane University, New Orleans, LA, USA.ORCID 0000-0001-5252-375X
Pia WeikopCenter for Translational Neuromedicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.ORCID 0000-0002-8422-1702
Steven A GoldmanCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-5498-4303
Michael J DavisDepartment of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, USA.
Maiken NedergaardCenter for Translational Neuromedicine, University of Rochester, Rochester, NY, USA. nedergaard@urmc.rochester.edu.
University of Rochester · USUniversity of Copenhagen · DKUniversity of Minnesota · USTulane University · USUniversity of Missouri · USUniversity of Rochester Medical Center · US
Funding
Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$13.6MLymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1MThe glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1MTRANSCRIPTIONAL DETERMINANTS OF THE FATE TRAJECTORIES OF SINGLE HUMAN GLIAL PROGENITOR CELLS IN RESPONSE TO DEMYELINATION IN VIVOR01NS110776 · NINDS · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2019 to 2023
$1.8MCRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6MCell-intrinsic and contextual determinants of aging by human glial progenitor cellsR01AG072298 · NIA · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2021 to 2025
$1.6MNCCIH NIH HHS R01 AT011439NCCIH NIH HHS R01 AT012312NHLBI NIH HHS R01 HL122578NIA NIH HHS R01 AG072298NINDS NIH HHS R01 NS110776NINDS NIH HHS U19 NS128613
Abstract
Cerebral oedema is associated with morbidity and mortality after traumatic brain injury (TBI)
Indexed as
Brain EdemaBrain Injuries, TraumaticGlymphatic SystemNorepinephrineAdrenergic AntagonistsAnimalsDisease Models, AnimalInflammationLymphatic VesselsMicePhosphorylationReceptors, Adrenergictau ProteinsAdrenergic AntagonistsMapt protein, mouseNorepinephrineReceptors, Adrenergictau Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.