ArticleNature2023
Stepwise requirements for polymerases δ and θ in theta-mediated end joining.
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In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
–field-weighted citation impact
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Who cites it
25 citing papers in PubMed.
- Activation of Pol theta-mediated end joining begins during mitotic commitment.bioRxiv : the preprint server for biology · 2026Article
- Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.Cell reports methods · 2026Article
- Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.Molecular cell · 2026Article
- Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis.Nature communications · 2026Article
- Beyond Short Microhomologies: Mismatch-Compatible Pol θ-Mediated DNA Damage Repair.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining at double-ended DSBs.Nucleic acids research · 2026Article
- Review
- Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Polymerase Ѳ inhibitors combinations with approved and investigational agents in patient-derived tumor multi-cell type (mct) spheroids.Experimental and molecular pathology · 2025Article
- Mechanisms and regulation of DNA end resection in the maintenance of genome stability.Nature reviews. Molecular cell biology · 2025Review
- Pol θ-mediated end-joining uses microhomologies containing mismatches.Nature communications · 2025Article
- Human polymerase θ helicase positions DNA microhomologies for double-strand break repair.Nature structural & molecular biology · 2025Article
- Making 3' ends meet.Nature structural & molecular biology · 2025Article
- Molecular mechanisms of extrachromosomal circular DNA formation.Nucleic acids research · 2025Review
- A mobile genetic element-derived primase-polymerase harbors multiple activities implicated in DNA replication and repair.Nucleic acids research · 2025Article
- RPA and Rad27 limit templated and inverted insertions at DNA breaks.Nucleic acids research · 2025Article
- Mechanisms of tandem duplication in the cancer genome.DNA repair · 2025Review
- Quinoline-based compounds can inhibit diverse enzymes that act on DNA.Cell chemical biology · 2024Article
- CRISPR/Cas9-induced double-strand breaks in the huntingtin locus lead to CAG repeat contraction through DNA end resection and homology-mediated repair.BMC biology · 2024Article
- Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome.DNA repair · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Susanna StroikLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Juan Carvajal-GarciaDepartment of Biochemistry, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-7257-3674
Dipika GuptaDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-6512-5256
Alyssa EdwardsCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-1968-7186
Adam LuthmanDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David W WyattLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rachel L DannenbergDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Wanjuan FengLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thomas A KunkelGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0002-9900-1788
Gaorav P GuptaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-9177-552X
Mark HedglinDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-2599-1691
Richard WoodDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center and The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.ORCID 0000-0002-9495-6892
Sylvie DoubliéDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA.
Eli RothenbergDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-1382-1380
Dale A RamsdenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Dale_ramsden@med.unc.edu.ORCID 0000-0003-1575-4748
Funding
Integrated Training in Cancer Model SystemsT32CA009156 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DER, CHANNING J. · 1985 to 2020
$19.7MStructural determinants of Pol theta functionP01CA247773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Gaorav P. Gupta · 2020 to 2026
$15.2MMechanisms of Human DNA Double-Strand Break Repair via Quantitative Single-Molecule Imaging - Equipment SupplementR35GM134947 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Eli Rothenberg · 2020 to 2026
$3.4MMechanism and Fidelity of RAG mediated DNA recombinationR01AI153040 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ROTHENBERG, ELI · 2020 to 2024
$2.7MDeciphering the progression and regulation of human translesion DNA synthesisR35GM147238 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Mark Hedglin · 2022 to 2026
$2.0MDNA Polymerases in Nonhomologous End JoiningU01CA097096 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2019 to 2022
$1.4MCharacterization of POLQ's Function in Replication RescueF32CA264891 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STROIK, SUSANNA JANE · 2021 to 2023
$199kNCI NIH HHS F32 CA264891NCI NIH HHS P01 CA247773NCI NIH HHS T32 CA009156NCI NIH HHS U01 CA097096NIAID NIH HHS R01 AI153040NIGMS NIH HHS R35 GM134947NIGMS NIH HHS R35 GM147238
Abstract
Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway has an important role in resolving these breaks and is essential in cancers defective in other DNA repair pathways, thus making it an emerging therapeutic target
Indexed as
DNA-Directed DNA PolymeraseDNA End-Joining RepairDNA Polymerase IIIDNADNA Polymerase thetaGenomic InstabilityDNADNA-Directed DNA PolymeraseDNA Polymerase IIIDNA Polymerase theta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.