Evidence map›Paper›PMID 37968389›Full record

ArticleNature2023

Embryo-scale reverse genetics at single-cell resolution.

Lauren M Saunders, Sanjay R Srivatsan, Madeleine Duran, Michael W Dorrity, Brent Ewing, Tor H Linbo, Jay Shendure, David W Raible, Cecilia B Moens, David Kimelman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Transcriptional profiling of extraocular motor neurons revealsbioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Zebrafish as a Model System for Polycystic Kidney Disease: Lessons from ift140 Mutants.Journal of the American Society of Nephrology : JASN · 2026
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lauren M Saunders *Department of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4377-4252
Sanjay R Srivatsan *Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Madeleine DuranDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1648-2369
Michael W DorrityDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7691-6504
Brent EwingDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Tor H LinboDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1516-1865
David W RaibleDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5342-5841
Cecilia B MoensFred Hutchinson Cancer Center, Seattle, WA, USA.
David KimelmanDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. kimelman@uw.edu.ORCID 0000-0002-9261-4506
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. coletrap@uw.edu.ORCID 0000-0002-8105-4347
University of Washington · USFred Hutch Cancer Center · USHoward Hughes Medical Institute · US

Funding

Versatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9M
Topographic mapping by cranial motor neurons - Renewal - Resubmission - 1R01NS109425 · NINDS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Cecilia B Moens · 2018 to 2026
$2.9M
New software tools for differential analysis of single-cell genomics perturbation experimentsR01HG012761 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Kimelman, Bruce Colston Trapnell · 2023 to 2026
$2.5M
Zebrafish Inner Ear RegenerationR21DC019948 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 2022 to 2023
$408k
NHGRI NIH HHS R01 HG010632NHGRI NIH HHS R01 HG012761NIDCD NIH HHS R21 DC019948NINDS NIH HHS R01 NS109425
6 · The paper itself

Abstract

The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from whole embryos

Indexed as

Embryo, MammalianReverse GeneticsSingle-Cell AnalysisZebrafishAnimalsBrachyury ProteinGene Expression ProfilingGene Expression Regulation, DevelopmentalMutationNotochordTranscriptomeBrachyury Protein

Identifiers

PMID37968389
PMCPMC10665197
OpenAlexW4388694332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.