ArticleNature2023
Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Genetic and genomic insights into male reproductive tract development.Fertility and sterility · 2025Pooled it
- Spatiotemporal development of sparse excitatory neuronal types within the deep mouse cortex.iScience · 2026Article
- LIGER2: Scalable Single-Cell Integration with On-Disk Datasets.bioRxiv : the preprint server for biology · 2026Article
- A developmental shift in glucocorticoid receptor expression preserves glucocorticoid sensitivity in the adult suprachiasmatic nucleus.PLoS biology · 2026Article
- Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapes.bioRxiv : the preprint server for biology · 2026Article
- Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq.bioRxiv : the preprint server for biology · 2026Article
- pertTF: context-aware AI modeling for genome-scale and cross-system perturbation prediction.bioRxiv : the preprint server for biology · 2026Article
- Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing.Cell genomics · 2026Article
- Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods.Nature reviews. Molecular cell biology · 2026Review
- Disrupted developmental signaling induces novel transcriptional states.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer.Science (New York, N.Y.) · 2025Article
- Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.Nature ecology & evolution · 2025Article
- Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens.bioRxiv : the preprint server for biology · 2025Article
- Single-cell technology grows up: Leveraging high-resolution omics approaches to understand neurodevelopmental disorders.Current opinion in neurobiology · 2025Review
- A fascination with tailless mice: a scientific historical review of studies of the T/t complex.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Golgi pH elevation due to loss of V-ATPase subunit V0a2 function correlates with tissue-specific glycosylation changes and globozoospermia.Cellular and molecular life sciences : CMLS · 2024Article
- Reconstructing human-specific regulatory functions in model systems.Current opinion in genetics & development · 2024Review
- Engineering structural variants to interrogate genome function.Nature genetics · 2024Review
- Impact of PARP inhibitors on progression-free survival in platinum-sensitive recurrent epithelial ovarian cancer: a retrospective analysis.World journal of surgical oncology · 2024Article
- Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly.Human genetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 13 institutions in 2 countries.
Xingfan Huang *Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Jana Henck *Institute of Human Genetics, University Medical Center Schleswig-Holstein, University of Lübeck & Kiel University, Lübeck, Germany.
Chengxiang Qiu *Department of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6346-8669
Varun K A SreenivasanInstitute of Human Genetics, University Medical Center Schleswig-Holstein, University of Lübeck & Kiel University, Lübeck, Germany.ORCID 0000-0002-8667-8394
Saranya BalachandranInstitute of Human Genetics, University Medical Center Schleswig-Holstein, University of Lübeck & Kiel University, Lübeck, Germany.
Oana V AmarieInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0003-1705-6812
Martin Hrabě de AngelisInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0002-7898-2353
Rose Yinghan BehnckeInstitute of Medical Genetics and Human Genetics of the Charité, Berlin, Germany.ORCID 0009-0005-8503-3411
Wing-Lee ChanInstitute of Medical Genetics and Human Genetics of the Charité, Berlin, Germany.
Alexandra DespangMax Planck Institute for Molecular Genetics, Berlin, Germany.
Diane E DickelLawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0001-5497-6824
Madeleine DuranDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1648-2369
Annette FeuchtingerCore Facility Pathology & Tissue Analytics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Helmut FuchsInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0002-5143-2677
Valerie Gailus-DurnerInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0002-6076-0111
Natja HaagInstitute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Rene HägerlingMax Planck Institute for Molecular Genetics, Berlin, Germany.
Nils HansmeierMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0001-7024-5351
Friederike HennigMax Planck Institute for Molecular Genetics, Berlin, Germany.
Cooper MarshallDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Sudha RajderkarLawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0003-2001-3450
Alessa RingelMax Planck Institute for Molecular Genetics, Berlin, Germany.
Michael RobsonMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0003-1126-3538
Lauren M SaundersDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4377-4252
Patricia da Silva-ButtkusInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Nadine SpielmannInstitute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Sanjay R SrivatsanDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Sascha UlfertsInstitute of Medical Genetics and Human Genetics of the Charité, Berlin, Germany.
Lars WittlerMax Planck Institute for Molecular Genetics, Berlin, Germany.
Yiwen ZhuGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-2282-1913
Vera M KalscheuerMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0001-6898-3259
Daniel M IbrahimMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-0019-3354
Ingo KurthInstitute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-5642-8378
Uwe KornakInstitute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-4582-9838
Axel ViselLawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-4130-7784
Len A PennacchioLawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-8748-3732
David R BeierBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8105-4347
Junyue CaoLaboratory of Single-Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. jcao@rockefeller.edu.ORCID 0000-0003-4097-489X
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. shendure@uw.edu.ORCID 0000-0002-1516-1865
Malte SpielmannInstitute of Human Genetics, University Medical Center Schleswig-Holstein, University of Lübeck & Kiel University, Lübeck, Germany. malte.spielmann@uksh.de.ORCID 0000-0002-0583-4683
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEHelmholtz Zentrum München · DEUniversity of Washington · USMax Planck Institute for Molecular Genetics · DELawrence Berkeley National Laboratory · USChristian-Albrechts-Universität zu Kiel · DERWTH Aachen University · DEDeutsches Diabetes-Zentrum e.V. · DEHoward Hughes Medical Institute · USRockefeller University · USSeattle Children's Hospital · USUniversitätsmedizin Göttingen · DEUniversity Hospital Schleswig-Holstein · DE
Funding
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MCenter for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1MMutagenesis and Murine Embyonic DevelopmentR01HD036404 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI BEIER, DAVID R. · 1998 to 2020
$8.1MIn Vivo Characterization of Major ENCODE-Predicted Classes of Noncoding ElementsUM1HG009421 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2017 to 2021
$6.8MVersatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9MA Single-Cell Resolution Enhancer Atlas of Craniofacial DevelopmentR01DE028599 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2019 to 2023
$4.2MEvaluating the Impact of Mutations in Distant-Acting Enhancers in Structural Birth DefectsR01HD114353 · NICHD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio, Axel Visel · 2023 to 2026
$3.3MSingle cell dynamics on a whole organism scaleDP2HG012522 · NHGRI · ROCKEFELLER UNIVERSITY · PI CAO, JUNYUE · 2021 to 2024
$2.5MNHGRI NIH HHS DP2 HG012522NHGRI NIH HHS R01 HG003988NHGRI NIH HHS R01 HG010632NHGRI NIH HHS RM1 HG011014NHGRI NIH HHS UM1 HG009421NICHD NIH HHS R01 HD036404NICHD NIH HHS R01 HD114353NIDCR NIH HHS R01 DE028599
Abstract
Mouse models are a critical tool for studying human diseases, particularly developmental disorders
Indexed as
Developmental DisabilitiesEmbryo, MammalianMutationPhenotypeSingle-Cell Gene Expression AnalysisAnimalsCell NucleusDisease Models, AnimalGain of Function MutationGenotypeLoss of Function MutationMiceModels, Genetic
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