ArticleNature2023
Clostridioides difficile ferrosome organelles combat nutritional immunity.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 49 citations in OpenAlex.
- The anti-diarrheal role of iron in piglets: Regulation of colonic goblet cell function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Review
- Ferrosome Organelles Spatially Insulate a Redox-Active Ferrous Phosphate Biomineral from Cytosolic ROS Chemistry.bioRxiv : the preprint server for biology · 2026Article
- Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study.The Journal of infectious diseases · 2026Article
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- Friction-driven scission: How nonlocal mechanisms contribute to membrane fission across domains of life.Science advances · 2026Review
- Visualizing Postsynaptic Density in Excitatory Synapses with Electron Tomography.Advances in neurobiology · 2026Review
- A network of coiled-coil and actin-like proteins controls the cellular organization of magnetosome organelles in deep-branching magnetotactic bacteria.Nature communications · 2025Article
- Dietary iron attenuatesVirulence · 2025Article
- Iron and the immune system.Nature reviews. Immunology · 2025Review
- CD44 is a macrophage receptor for TcdB fromGut microbes · 2025Article
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- Unravelling three-way interactions betweenJournal of medical microbiology · 2025Review
- The exploitation of nutrient metals by bacteria for survival and infection in the gut.PLoS pathogens · 2025Review
- Engineering Spatial Control of Bacterial Organelles.bioRxiv : the preprint server for biology · 2025Article
- A network of coiled-coil and actin-like proteins controls the cellular organization of magnetosome organelles in deep-branching magnetotactic bacteria.bioRxiv : the preprint server for biology · 2025Article
- In situ cryo-electron microscopy and tomography of cellular and organismal samples.Current opinion in structural biology · 2025Review
- Viruses hijack FPN1 to disrupt iron withholding and suppress host defense.Nature communications · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Iron at the crossroads of host-microbiome interactions in health and disease.Nature microbiology · 2025Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Hualiang Pi *Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-0015-4443
Rong Sun *Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-0950-1480
James R McBrideVanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-0161-7283
Angela R S KruseMass Spectrometry Research Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-8776-2769
Katherine N Gibson-CorleyDepartment of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1846-1580
Evan S KrystofiakDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-0043-6977
Maribeth R NicholsonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey M SpragginsDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-9198-5498
Qiangjun ZhouDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. qiangjun.zhou@Vanderbilt.Edu.ORCID 0000-0003-1789-9588
Eric P SkaarVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, TN, USA. eric.skaar@vumc.org.ORCID 0000-0001-5094-8105
Vanderbilt University · USVanderbilt University Medical Center · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MVanderbilt Antibody and Antigen Discovery for Clostridioides difficile VaccinesU19AI174999 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2023 to 2026
$7.9MPathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9MMolecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2MNutritional immunity and microbial competition during Clostridioides difficile infectionR01AI164587 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2022 to 2025
$2.4MThermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0MImmune, Microbial, and Metabolic Factors that Impact Clostridioides difficile and Inflammatory Bowel Disease in ChildrenK23AI156132 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NICHOLSON, MARIBETH RUTH · 2021 to 2025
$876kMolecular Mechanism and Regulation of Asynchronous ReleaseR00MH113764 · NIMH · VANDERBILT UNIVERSITY · PI ZHOU, QIANGJUN · 2020 to 2022
$719kNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIAID NIH HHS F32 AI161860NIAID NIH HHS K23 AI156132NIAID NIH HHS K99 AI168483NIAID NIH HHS R00 AI168483NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI164587NIAID NIH HHS U19 AI174999NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS S10 OD030292NIMH NIH HHS R00 MH113764
Abstract
Iron is indispensable for almost all forms of life but toxic at elevated levels
Indexed as
Clostridioides difficileClostridium InfectionsFerric CompoundsHost Microbial InteractionsIronOrganellesAnimalsBacterial ProteinsCell MembraneCryoelectron MicroscopyDisease Models, AnimalElectron Microscope TomographyHomeostasisInflammationIntestinesLeukocyte L1 Antigen ComplexBacterial ProteinsFerric CompoundsferrosomeIronLeukocyte L1 Antigen Complex
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.